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Behavioral manipulation of the diabetic phenotype in ob/ob mice.

Publication ,  Journal Article
Surwit, RS; Feinglos, MN; Livingston, EG; Kuhn, CM; McCubbin, JA
Published in: Diabetes
July 1984

The genetically obese mouse (C57BL/6J ob/ob) is a commonly used model of non-insulin-dependent diabetes mellitus. However, our studies demonstrate that, while the animal is significantly hyperinsulinemic, it in fact does not show consistent hyperglycemia in the resting state. During stress, both obese animals and their lean littermates become hyperglycemic, but the magnitude of the hyperglycemia is exaggerated in the obese mice. Obese animals also show an exaggerated plasma glucose increase in response to epinephrine injection. This increase in plasma glucose is accompanied by a decrease in plasma insulin in response to both stress and epinephrine. Our findings suggest that environmental stimuli influence the expression of diabetes in the C57BL/6J obese mouse and therefore must be considered in studies of this animal model of diabetes.

Duke Scholars

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

July 1984

Volume

33

Issue

7

Start / End Page

616 / 618

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Rodent Diseases
  • Restraint, Physical
  • Phenotype
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Handling, Psychological
  • Epinephrine
 

Citation

APA
Chicago
ICMJE
MLA
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Surwit, R. S., Feinglos, M. N., Livingston, E. G., Kuhn, C. M., & McCubbin, J. A. (1984). Behavioral manipulation of the diabetic phenotype in ob/ob mice. Diabetes, 33(7), 616–618. https://doi.org/10.2337/diab.33.7.616
Surwit, R. S., M. N. Feinglos, E. G. Livingston, C. M. Kuhn, and J. A. McCubbin. “Behavioral manipulation of the diabetic phenotype in ob/ob mice.Diabetes 33, no. 7 (July 1984): 616–18. https://doi.org/10.2337/diab.33.7.616.
Surwit RS, Feinglos MN, Livingston EG, Kuhn CM, McCubbin JA. Behavioral manipulation of the diabetic phenotype in ob/ob mice. Diabetes. 1984 Jul;33(7):616–8.
Surwit, R. S., et al. “Behavioral manipulation of the diabetic phenotype in ob/ob mice.Diabetes, vol. 33, no. 7, July 1984, pp. 616–18. Pubmed, doi:10.2337/diab.33.7.616.
Surwit RS, Feinglos MN, Livingston EG, Kuhn CM, McCubbin JA. Behavioral manipulation of the diabetic phenotype in ob/ob mice. Diabetes. 1984 Jul;33(7):616–618.

Published In

Diabetes

DOI

ISSN

0012-1797

Publication Date

July 1984

Volume

33

Issue

7

Start / End Page

616 / 618

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Rodent Diseases
  • Restraint, Physical
  • Phenotype
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Handling, Psychological
  • Epinephrine