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Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.

Publication ,  Journal Article
Kuhn, CM; Cochrane, C; Feinglos, MN; Surwit, RS
Published in: Pharmacol Biochem Behav
March 1987

The present study investigated the contribution of altered sympathetic reactivity to the stress-induced hyperglycemia observed in the c57BL/6J (ob/ob) mouse, an animal model of type II diabetes. Blood glucose and insulin responses to sympathetic agonist and antagonist administration were evaluated in ob/ob mice and their nondiabetic, lean (ob/?) littermates. In addition, the ability of nutritional status to modify these responses was determined. These studies demonstrated that epinephrine administration to ob/ob mice caused an exaggerated increase in blood glucose and decrease in plasma insulin in ob/ob mice relative to lean littermates. The dose response curve for epinephrine-induced increases in blood glucose were shifted to the left, and the duration of the blood glucose and plasma insulin responses was longer. Differences between ob/ob mice and their nondiabetic littermates were greater when animals were tested in the fasted state. In addition, administration of the alpha adrenergic antagonist phentolamine caused a larger increase in plasma insulin in ob/ob mice than was observed in lean littermates. These results suggest that altered peripheral responses to sympathetic stimuli contribute to stress-induced hyperglycemia in ob/ob mice, and raise the possibility that altered sympathetic function is an etiologic factor in development of diabetes in these animals.

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Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

March 1987

Volume

26

Issue

3

Start / End Page

491 / 495

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Phentolamine
  • Obesity
  • Neurology & Neurosurgery
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Hyperglycemia
  • Fasting
 

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Kuhn, C. M., Cochrane, C., Feinglos, M. N., & Surwit, R. S. (1987). Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. Pharmacol Biochem Behav, 26(3), 491–495. https://doi.org/10.1016/0091-3057(87)90154-7
Kuhn, C. M., C. Cochrane, M. N. Feinglos, and R. S. Surwit. “Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.Pharmacol Biochem Behav 26, no. 3 (March 1987): 491–95. https://doi.org/10.1016/0091-3057(87)90154-7.
Kuhn CM, Cochrane C, Feinglos MN, Surwit RS. Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. Pharmacol Biochem Behav. 1987 Mar;26(3):491–5.
Kuhn, C. M., et al. “Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse.Pharmacol Biochem Behav, vol. 26, no. 3, Mar. 1987, pp. 491–95. Pubmed, doi:10.1016/0091-3057(87)90154-7.
Kuhn CM, Cochrane C, Feinglos MN, Surwit RS. Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. Pharmacol Biochem Behav. 1987 Mar;26(3):491–495.
Journal cover image

Published In

Pharmacol Biochem Behav

DOI

ISSN

0091-3057

Publication Date

March 1987

Volume

26

Issue

3

Start / End Page

491 / 495

Location

United States

Related Subject Headings

  • Stress, Physiological
  • Phentolamine
  • Obesity
  • Neurology & Neurosurgery
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Hyperglycemia
  • Fasting