Neuroendocrine response to cold in Raynaud's syndrome.
Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly higher levels of cortisol during a cold challenge than either ANA positive patients or normal controls, and exhibited significantly lower levels of plasma norepinephrine compared with normal controls. ANA positive patients did not differ significantly from normals in their neuroendocrine response to cold. It is suggested that the high plasma cortisol found in Raynaud's syndrome in the absence of ANA may be responsible for the vasospasticity in this group of patients.
Duke Scholars
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Related Subject Headings
- Time Factors
- Raynaud Disease
- Pharmacology & Pharmacy
- Norepinephrine
- Hydrocortisone
- Humans
- Female
- Cold Temperature
- Antibodies, Antinuclear
- 3214 Pharmacology and pharmaceutical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Time Factors
- Raynaud Disease
- Pharmacology & Pharmacy
- Norepinephrine
- Hydrocortisone
- Humans
- Female
- Cold Temperature
- Antibodies, Antinuclear
- 3214 Pharmacology and pharmaceutical sciences