Failure of genetically selected miniature swine to model NIDDM.
Publication
, Journal Article
Hand, MS; Surwit, RS; Rodin, J; Van Order, P; Feinglos, MN
Published in: Diabetes
March 1987
Ten young adult miniature swine from a line reported to be genetically selected for glucose intolerance and eight normal controls were obtained from Colorado State University. They were consecutively exposed to 4 mo of a high-fiber, low-fat standard swine diet; 4 mo of a high-sucrose, high-fat, low-fiber diabetogenic diet; and 4 mo of excess diabetogenic diet for obesification. Results of oral glucose tolerance and intravenous insulin tolerance tests conducted at the end of each regimen were compared. Hyperglycemia was not observed in any animals after any manipulation. Insulin sensitivity was also not influenced by diet. We conclude that F7 low-K miniature swine from this colony fail to model human non-insulin-dependent diabetes.
Duke Scholars
Published In
Diabetes
DOI
ISSN
0012-1797
Publication Date
March 1987
Volume
36
Issue
3
Start / End Page
284 / 287
Location
United States
Related Subject Headings
- Swine, Miniature
- Swine
- Male
- Insulin
- Glucose Tolerance Test
- Female
- Endocrinology & Metabolism
- Disease Models, Animal
- Diet
- Diabetes Mellitus, Type 2
Citation
APA
Chicago
ICMJE
MLA
NLM
Hand, M. S., Surwit, R. S., Rodin, J., Van Order, P., & Feinglos, M. N. (1987). Failure of genetically selected miniature swine to model NIDDM. Diabetes, 36(3), 284–287. https://doi.org/10.2337/diab.36.3.284
Hand, M. S., R. S. Surwit, J. Rodin, P. Van Order, and M. N. Feinglos. “Failure of genetically selected miniature swine to model NIDDM.” Diabetes 36, no. 3 (March 1987): 284–87. https://doi.org/10.2337/diab.36.3.284.
Hand MS, Surwit RS, Rodin J, Van Order P, Feinglos MN. Failure of genetically selected miniature swine to model NIDDM. Diabetes. 1987 Mar;36(3):284–7.
Hand, M. S., et al. “Failure of genetically selected miniature swine to model NIDDM.” Diabetes, vol. 36, no. 3, Mar. 1987, pp. 284–87. Pubmed, doi:10.2337/diab.36.3.284.
Hand MS, Surwit RS, Rodin J, Van Order P, Feinglos MN. Failure of genetically selected miniature swine to model NIDDM. Diabetes. 1987 Mar;36(3):284–287.
Published In
Diabetes
DOI
ISSN
0012-1797
Publication Date
March 1987
Volume
36
Issue
3
Start / End Page
284 / 287
Location
United States
Related Subject Headings
- Swine, Miniature
- Swine
- Male
- Insulin
- Glucose Tolerance Test
- Female
- Endocrinology & Metabolism
- Disease Models, Animal
- Diet
- Diabetes Mellitus, Type 2