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Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.

Publication ,  Journal Article
Morrell, EM; Surwit, RS; Kuhn, CM; Feinglos, MN; Cochrane, C
Published in: Psychosom Med
1988

The obese (C57BL/6J ob/ob) mouse is a commonly used animal model of non-insulin-dependent diabetes mellitus. Recent experiments have shown that stress hyperglycemia can be classically conditioned in the obese but not in the lean mouse. In the present study, classical conditioning of insulin secretion was attempted in C57BL/6J obese and lean animals. For 21 days, obese and lean mice were exposed to a conditioned olfactory stimulus prior to and during eating. On the 22nd day, blood was sampled for all animals following presentation of the conditioned stimulus; testing was repeated 2 weeks later following an additional 4 days of conditioning. Results indicated an effect of conditioning, with significantly greater plasma insulin for trained than for untrained obese mice. That insulin secretion can be more easily conditioned in the obese mouse suggests that a cholinergic mechanism may be involved in the hyperinsulinemia characteristic of this animal.

Duke Scholars

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1988

Volume

50

Issue

6

Start / End Page

586 / 590

Location

United States

Related Subject Headings

  • Smell
  • Psychiatry
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Insulin
  • Conditioning, Classical
  • Body Weight
  • Blood Glucose
 

Citation

APA
Chicago
ICMJE
MLA
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Morrell, E. M., Surwit, R. S., Kuhn, C. M., Feinglos, M. N., & Cochrane, C. (1988). Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. Psychosom Med, 50(6), 586–590. https://doi.org/10.1097/00006842-198811000-00004
Morrell, E. M., R. S. Surwit, C. M. Kuhn, M. N. Feinglos, and C. Cochrane. “Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.Psychosom Med 50, no. 6 (1988): 586–90. https://doi.org/10.1097/00006842-198811000-00004.
Morrell EM, Surwit RS, Kuhn CM, Feinglos MN, Cochrane C. Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. Psychosom Med. 1988;50(6):586–90.
Morrell, E. M., et al. “Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse.Psychosom Med, vol. 50, no. 6, 1988, pp. 586–90. Pubmed, doi:10.1097/00006842-198811000-00004.
Morrell EM, Surwit RS, Kuhn CM, Feinglos MN, Cochrane C. Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. Psychosom Med. 1988;50(6):586–590.

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1988

Volume

50

Issue

6

Start / End Page

586 / 590

Location

United States

Related Subject Headings

  • Smell
  • Psychiatry
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Insulin
  • Conditioning, Classical
  • Body Weight
  • Blood Glucose