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Alprazolam reduces stress hyperglycemia in ob/ob mice.

Publication ,  Journal Article
Surwit, RS; McCubbin, JA; Kuhn, CM; McGee, D; Gerstenfeld, D; Feinglos, MN
Published in: Psychosom Med
1986

We have shown that the C57BL/6J ob/ob (obese) mouse, a commonly used model of type II diabetes mellitus, is not in fact consistently hyperglycemic except when exposed to environmental stress. In an attempt to modify stress hyperglycemia in this animal, we administered either a 5 mg/kg dose of the benzodiazepine alprazolam or vehicle (propylene glycol) intraperitoneally to both obese mice and their lean littermates prior to a rest and a stress period. Alprazolam modified the hyperglycemic effect of stress only in the obese mice. Alprazolam significantly reduced plasma corticosterone in obese animals at rest and following stress. In addition, alprazolam significantly increased plasma insulin in all animals at rest and following stress. These data suggest a possible role for benzodiazepines in the modification of stress hyperglycemia in type II diabetes mellitus.

Duke Scholars

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1986

Volume

48

Issue

3-4

Start / End Page

278 / 282

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Psychiatry
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Hyperglycemia
  • Diabetes Mellitus, Experimental
  • Blood Glucose
  • Benzodiazepines
 

Citation

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Surwit, R. S., McCubbin, J. A., Kuhn, C. M., McGee, D., Gerstenfeld, D., & Feinglos, M. N. (1986). Alprazolam reduces stress hyperglycemia in ob/ob mice. Psychosom Med, 48(3–4), 278–282. https://doi.org/10.1097/00006842-198603000-00013
Surwit, R. S., J. A. McCubbin, C. M. Kuhn, D. McGee, D. Gerstenfeld, and M. N. Feinglos. “Alprazolam reduces stress hyperglycemia in ob/ob mice.Psychosom Med 48, no. 3–4 (1986): 278–82. https://doi.org/10.1097/00006842-198603000-00013.
Surwit RS, McCubbin JA, Kuhn CM, McGee D, Gerstenfeld D, Feinglos MN. Alprazolam reduces stress hyperglycemia in ob/ob mice. Psychosom Med. 1986;48(3–4):278–82.
Surwit, R. S., et al. “Alprazolam reduces stress hyperglycemia in ob/ob mice.Psychosom Med, vol. 48, no. 3–4, 1986, pp. 278–82. Pubmed, doi:10.1097/00006842-198603000-00013.
Surwit RS, McCubbin JA, Kuhn CM, McGee D, Gerstenfeld D, Feinglos MN. Alprazolam reduces stress hyperglycemia in ob/ob mice. Psychosom Med. 1986;48(3–4):278–282.

Published In

Psychosom Med

DOI

ISSN

0033-3174

Publication Date

1986

Volume

48

Issue

3-4

Start / End Page

278 / 282

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Psychiatry
  • Mice, Obese
  • Mice, Inbred C57BL
  • Mice
  • Insulin
  • Hyperglycemia
  • Diabetes Mellitus, Experimental
  • Blood Glucose
  • Benzodiazepines