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Adaptive mechanisms that preserve cardiac function in mice without myoglobin.

Publication ,  Journal Article
Meeson, AP; Radford, N; Shelton, JM; Mammen, PP; DiMaio, JM; Hutcheson, K; Kong, Y; Elterman, J; Williams, RS; Garry, DJ
Published in: Circ Res
April 13, 2001

Mice lacking myoglobin survive to adulthood and meet the circulatory demands of exercise and pregnancy without cardiac decompensation. In the present study, we show that many myoglobin-deficient embryos die in utero at midgestation with signs of cardiac failure. Fetal mice that survive to gestational day 12.5, however, suffer no subsequent excess mortality. Survival in the absence of myoglobin is associated with increased vascularity and the induction of genes encoding the hypoxia-inducible transcription factors 1alpha and 2, stress proteins such as heat shock protein 27, and vascular endothelial growth factor. These adaptations are evident in late fetal life, persist into adulthood, and are sufficient to maintain normal myocardial oxygen consumption during stressed conditions. These data reveal that myoglobin is necessary to support cardiac function during development, but adaptive responses evoked in some animals can fully compensate for the defect in cellular oxygen transport resulting from the loss of myoglobin.

Duke Scholars

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 13, 2001

Volume

88

Issue

7

Start / End Page

713 / 720

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Transcription Factors
  • Trans-Activators
  • Survival Rate
  • Phenotype
  • Oxygen Consumption
  • Nuclear Proteins
  • Myoglobin
  • Myocardium
 

Citation

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Meeson, A. P., Radford, N., Shelton, J. M., Mammen, P. P., DiMaio, J. M., Hutcheson, K., … Garry, D. J. (2001). Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res, 88(7), 713–720. https://doi.org/10.1161/hh0701.089753
Meeson, A. P., N. Radford, J. M. Shelton, P. P. Mammen, J. M. DiMaio, K. Hutcheson, Y. Kong, J. Elterman, R. S. Williams, and D. J. Garry. “Adaptive mechanisms that preserve cardiac function in mice without myoglobin.Circ Res 88, no. 7 (April 13, 2001): 713–20. https://doi.org/10.1161/hh0701.089753.
Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, et al. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713–20.
Meeson, A. P., et al. “Adaptive mechanisms that preserve cardiac function in mice without myoglobin.Circ Res, vol. 88, no. 7, Apr. 2001, pp. 713–20. Pubmed, doi:10.1161/hh0701.089753.
Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circ Res. 2001 Apr 13;88(7):713–720.

Published In

Circ Res

DOI

EISSN

1524-4571

Publication Date

April 13, 2001

Volume

88

Issue

7

Start / End Page

713 / 720

Location

United States

Related Subject Headings

  • Vascular Endothelial Growth Factors
  • Vascular Endothelial Growth Factor A
  • Transcription Factors
  • Trans-Activators
  • Survival Rate
  • Phenotype
  • Oxygen Consumption
  • Nuclear Proteins
  • Myoglobin
  • Myocardium