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Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans.

Publication ,  Journal Article
McLeod, AA; Brown, JE; Kitchell, BB; Sedor, FA; Kuhn, C; Shand, DG; Williams, RS
Published in: J Appl Physiol Respir Environ Exerc Physiol
March 1984

The effects of acute alpha 1-adrenoceptor blockade with prazosin, beta 1-adrenoceptor blockade with atenolol, and nonselective beta-adrenoceptor blockade with propranolol were compared in a placebo-controlled crossover study of the hemodynamic and metabolic responses to acute exercise 2 h after prolonged prior exercise to induce skeletal muscle glycogen depletion, enhancing the dependence on hepatic glucose output and circulating free fatty acids (FFA). Plasma catecholamines were higher during exercise after, as opposed to before, glycogen depletion and were elevated further by all three drugs. Propranolol failed to produce a significant reduction in systolic blood pressure and elevated diastolic blood pressure. Atenolol reduced systolic blood pressure and did not change diastolic blood pressure. Both beta-blockers reduced FFA levels, but only propranolol lowered plasma glucose relative to placebo during exercise after glycogen depletion. In contrast, prazosin reduced systolic and diastolic blood pressures and resulted in elevated FFA and glucose levels. The results indicate important differences in the hemodynamic effects of beta 1-selective vs. nonselective beta-blockade during exercise after skeletal muscle glycogen depletion. Furthermore they confirm the importance of beta 2-mediated hepatic glucose production in maintaining plasma glucose levels during exercise. Acute alpha 1-blockade with prazosin induces reflex elevation of catecholamines, which in the absence of blockade of hepatic beta 2-receptors produces elevation of plasma glucose. The results suggest there is little role for alpha 1-mediated hepatic glucose production during exercise in humans.

Duke Scholars

Published In

J Appl Physiol Respir Environ Exerc Physiol

DOI

ISSN

0161-7567

Publication Date

March 1984

Volume

56

Issue

3

Start / End Page

716 / 722

Location

United States

Related Subject Headings

  • Propranolol
  • Prazosin
  • Physiology
  • Physical Exertion
  • Norepinephrine
  • Male
  • Humans
  • Hemodynamics
  • Glycogen
  • Fatty Acids, Nonesterified
 

Citation

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ICMJE
MLA
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McLeod, A. A., Brown, J. E., Kitchell, B. B., Sedor, F. A., Kuhn, C., Shand, D. G., & Williams, R. S. (1984). Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans. J Appl Physiol Respir Environ Exerc Physiol, 56(3), 716–722. https://doi.org/10.1152/jappl.1984.56.3.716
McLeod, A. A., J. E. Brown, B. B. Kitchell, F. A. Sedor, C. Kuhn, D. G. Shand, and R. S. Williams. “Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans.J Appl Physiol Respir Environ Exerc Physiol 56, no. 3 (March 1984): 716–22. https://doi.org/10.1152/jappl.1984.56.3.716.
McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Shand DG, et al. Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):716–22.
McLeod, A. A., et al. “Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans.J Appl Physiol Respir Environ Exerc Physiol, vol. 56, no. 3, Mar. 1984, pp. 716–22. Pubmed, doi:10.1152/jappl.1984.56.3.716.
McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn C, Shand DG, Williams RS. Hemodynamic and metabolic responses to exercise after adrenoceptor blockade in humans. J Appl Physiol Respir Environ Exerc Physiol. 1984 Mar;56(3):716–722.

Published In

J Appl Physiol Respir Environ Exerc Physiol

DOI

ISSN

0161-7567

Publication Date

March 1984

Volume

56

Issue

3

Start / End Page

716 / 722

Location

United States

Related Subject Headings

  • Propranolol
  • Prazosin
  • Physiology
  • Physical Exertion
  • Norepinephrine
  • Male
  • Humans
  • Hemodynamics
  • Glycogen
  • Fatty Acids, Nonesterified