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The role of modulatory calcineurin-interacting proteins in calcineurin signaling.

Publication ,  Journal Article
Rothermel, BA; Vega, RB; Williams, RS
Published in: Trends Cardiovasc Med
January 2003

Modulatory calcineurin-interacting proteins (MCIPs), also known as the Down syndrome critical region 1 (DSCR1) and DSCR1-like proteins, are a recently described family of small, structurally related proteins that are preferentially expressed in heart, skeletal muscle, and brain. MCIP proteins can bind to and inhibit calcineurin, a calcium/calmodulin-regulated serine/threonine protein phosphatase that is activated during cardiac hypertrophy and failure. Transcription of the mammalian MCIP1 gene is induced by calcineurin, suggesting that it functions as an endogenous feedback regulator of calcineurin signal transduction. Forced expression of human MCIP1 protein in the hearts of transgenic mice attenuates the hypertrophic response to a broad range of stimuli. This review summarizes work from a number of laboratories on the structure, regulation, and function of MCIP proteins.

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Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

January 2003

Volume

13

Issue

1

Start / End Page

15 / 21

Location

United States

Related Subject Headings

  • Signal Transduction
  • Muscle Proteins
  • Mice
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Heart Failure
  • Gene Expression Regulation
  • DNA-Binding Proteins
  • Cardiovascular System & Hematology
  • Cardiomyopathy, Hypertrophic
 

Citation

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Rothermel, B. A., Vega, R. B., & Williams, R. S. (2003). The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc Med, 13(1), 15–21. https://doi.org/10.1016/s1050-1738(02)00188-3
Rothermel, Beverly A., Rick B. Vega, and R Sanders Williams. “The role of modulatory calcineurin-interacting proteins in calcineurin signaling.Trends Cardiovasc Med 13, no. 1 (January 2003): 15–21. https://doi.org/10.1016/s1050-1738(02)00188-3.
Rothermel BA, Vega RB, Williams RS. The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc Med. 2003 Jan;13(1):15–21.
Rothermel, Beverly A., et al. “The role of modulatory calcineurin-interacting proteins in calcineurin signaling.Trends Cardiovasc Med, vol. 13, no. 1, Jan. 2003, pp. 15–21. Pubmed, doi:10.1016/s1050-1738(02)00188-3.
Rothermel BA, Vega RB, Williams RS. The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc Med. 2003 Jan;13(1):15–21.
Journal cover image

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

January 2003

Volume

13

Issue

1

Start / End Page

15 / 21

Location

United States

Related Subject Headings

  • Signal Transduction
  • Muscle Proteins
  • Mice
  • Intracellular Signaling Peptides and Proteins
  • Humans
  • Heart Failure
  • Gene Expression Regulation
  • DNA-Binding Proteins
  • Cardiovascular System & Hematology
  • Cardiomyopathy, Hypertrophic