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Intraventricular CCK inhibits food intake and gastric emptying in baboons.

Publication ,  Journal Article
Figlewicz, DP; Sipols, AJ; Porte, D; Woods, SC; Liddle, RA
Published in: Am J Physiol
June 1989

To evaluate the role of cholecystokinin (CCK) as a physiological regulator of meal size and gastric emptying in the baboon, we measured plasma CCK bioactivity during 30-min meals alone and after intravenous or intraventricular infusions of CCK COOH-terminal octapeptide (CCK-8). Both intravenous (2 micrograms/kg) and intraventricular (1 microgram/kg) CCK-8 administration resulted in plasma CCK elevations comparable with normal prandial CCK levels: peak plasma levels were 4.1 +/- 0.9, 7.1 +/- 1.1, and 4.9 +/- 2.2 pM for pooled intravenous and intraventricular control, intravenous, and intraventricular conditions. Also, both treatments appeared to reduce gastric emptying as indicated by a significant suppression of postprandial plasma insulin and glucose levels. However, only intraventricular CCK reliably reduced meal size (percent of control meal size was 91 +/- 5% or 43 +/- 19% with intravenous or intraventricular CCK). We conclude that circulating endogenous CCK is a potent postprandial endocrine regulator of gastric emptying. However, the ability of CCK to decrease meal size may require direct interaction with the central nervous system.

Duke Scholars

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1989

Volume

256

Issue

6 Pt 2

Start / End Page

R1313 / R1317

Location

United States

Related Subject Headings

  • Sincalide
  • Satiation
  • Reference Values
  • Papio
  • Male
  • Kinetics
  • Injections, Intraventricular
  • Infusions, Intravenous
  • Gastric Emptying
  • Cholecystokinin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Figlewicz, D. P., Sipols, A. J., Porte, D., Woods, S. C., & Liddle, R. A. (1989). Intraventricular CCK inhibits food intake and gastric emptying in baboons. Am J Physiol, 256(6 Pt 2), R1313–R1317. https://doi.org/10.1152/ajpregu.1989.256.6.R1313
Figlewicz, D. P., A. J. Sipols, D. Porte, S. C. Woods, and R. A. Liddle. “Intraventricular CCK inhibits food intake and gastric emptying in baboons.Am J Physiol 256, no. 6 Pt 2 (June 1989): R1313–17. https://doi.org/10.1152/ajpregu.1989.256.6.R1313.
Figlewicz DP, Sipols AJ, Porte D, Woods SC, Liddle RA. Intraventricular CCK inhibits food intake and gastric emptying in baboons. Am J Physiol. 1989 Jun;256(6 Pt 2):R1313–7.
Figlewicz, D. P., et al. “Intraventricular CCK inhibits food intake and gastric emptying in baboons.Am J Physiol, vol. 256, no. 6 Pt 2, June 1989, pp. R1313–17. Pubmed, doi:10.1152/ajpregu.1989.256.6.R1313.
Figlewicz DP, Sipols AJ, Porte D, Woods SC, Liddle RA. Intraventricular CCK inhibits food intake and gastric emptying in baboons. Am J Physiol. 1989 Jun;256(6 Pt 2):R1313–R1317.

Published In

Am J Physiol

DOI

ISSN

0002-9513

Publication Date

June 1989

Volume

256

Issue

6 Pt 2

Start / End Page

R1313 / R1317

Location

United States

Related Subject Headings

  • Sincalide
  • Satiation
  • Reference Values
  • Papio
  • Male
  • Kinetics
  • Injections, Intraventricular
  • Infusions, Intravenous
  • Gastric Emptying
  • Cholecystokinin