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Cholecystokinin does not stimulate prosomatostatin-derived peptides in man.

Publication ,  Journal Article
Liddle, RA; Ensinck, JW
Published in: J Clin Endocrinol Metab
May 1990

In man, plasma cholecystokinin (CCK) and somatostatin-28 (S-28) levels increase after ingestion of a mixed meal. Both peptides originate from the gastrointestinal tract. In supra- and periphysiological doses, CCK stimulates the release of somatostatin-14 from in vitro pancreatic islets and gastric cells and increases circulating somatostatin-like immunoreactivity in dogs, leading to the conjecture that CCK regulates somatostatin-like immunoreactivity secretion. Nonetheless, whether CCK is responsible in part for the meal-induced rise in S-28 in man has not been established. Therefore, the present study was designed to determine if CCK, at both physiological and supraphysiological concentrations, increases the circulating levels of prosomatostatin (proS)-derived peptides in humans. On 3 separate days, five healthy men ate a mixed liquid meal or received iv infusions of CCK at rates of 18 or 38 pmol/kg.h. Plasma levels of pro-S-derived peptides, including pro-S, S-14, S-13, S-28, and CCK, were measured. Basal CCK levels averaged 0.9 +/- 0.1 pmol/L and increased after the meal to a peak level of 5.4 +/- 1.5 pmol/L and averaged 3.1 +/- 1.2 pmol/L over 90 min. The mean basal levels of pro-S, S-14, and S-13, measured collectively, was 6.1 +/- 0.4 pmol/L eq S14 and was unaltered by food intake. The S-28 level was 6.7 +/- 0.6 pmol/L and rose to a zenith of 13.1 +/- 3.3 pmol/L by 90 min. Infusion of CCK at 18 and 38 pmol/kg.h produced steady state plasma CCK levels of 4.1 +/- 1.1 and 9.9 +/- 1.5 pmol/L, respectively. Basal levels of pro-S-derived peptides were unaltered during the infusion of either the low or high dose of CCK. We conclude that CCK by itself is not a physiological signal to the release of pro-S-derived peptides in man.

Duke Scholars

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

May 1990

Volume

70

Issue

5

Start / End Page

1403 / 1407

Location

United States

Related Subject Headings

  • Somatostatin-28
  • Somatostatin
  • Sincalide
  • Protein Precursors
  • Peptides
  • Male
  • Infusions, Intravenous
  • Humans
  • Endocrinology & Metabolism
  • Eating
 

Citation

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MLA
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Liddle, R. A., & Ensinck, J. W. (1990). Cholecystokinin does not stimulate prosomatostatin-derived peptides in man. J Clin Endocrinol Metab, 70(5), 1403–1407. https://doi.org/10.1210/jcem-70-5-1403
Liddle, R. A., and J. W. Ensinck. “Cholecystokinin does not stimulate prosomatostatin-derived peptides in man.J Clin Endocrinol Metab 70, no. 5 (May 1990): 1403–7. https://doi.org/10.1210/jcem-70-5-1403.
Liddle RA, Ensinck JW. Cholecystokinin does not stimulate prosomatostatin-derived peptides in man. J Clin Endocrinol Metab. 1990 May;70(5):1403–7.
Liddle, R. A., and J. W. Ensinck. “Cholecystokinin does not stimulate prosomatostatin-derived peptides in man.J Clin Endocrinol Metab, vol. 70, no. 5, May 1990, pp. 1403–07. Pubmed, doi:10.1210/jcem-70-5-1403.
Liddle RA, Ensinck JW. Cholecystokinin does not stimulate prosomatostatin-derived peptides in man. J Clin Endocrinol Metab. 1990 May;70(5):1403–1407.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

ISSN

0021-972X

Publication Date

May 1990

Volume

70

Issue

5

Start / End Page

1403 / 1407

Location

United States

Related Subject Headings

  • Somatostatin-28
  • Somatostatin
  • Sincalide
  • Protein Precursors
  • Peptides
  • Male
  • Infusions, Intravenous
  • Humans
  • Endocrinology & Metabolism
  • Eating