Skip to main content
Journal cover image

Renal and hepatic lysosomal catabolism of luteinizing hormone.

Publication ,  Journal Article
Ascoli, M; Liddle, RA; Puett, D
Published in: Mol Cell Endocrinol
May 1976

Following an intravenous injection of tritiated ovine lutenizing hormone (LH) into mature male rats, the liver and kidneys accumulate a significant portion of the non-excreted hormone. The subcellular distribution of total radioactivity in both tissues was found to be similar to that of beta-galactosidase, a lysosomal enzyme marker. Moreover, the subcellular fraction with the highest relative specific activity of beta-galactosidase exhibited the highest degradation rate of endogenous hormone under in vitro conditions. Based on these and other observations, it is concluded that the intracellular catabolism of LH by these tissues is due to lysosomal enzymes. An analysis of the radioactive degradation products produced by a lysosomal-rich subcellular fraction showed the presence of free amino acids and oligopeptides. Thus, the uptake and degradation of the hormone by these tissues appear to occur by endocytosis followed by lysosomal catabolism. This phenomenon may represent a regulatory role in the control of (circulating) hormone concenttrations.

Duke Scholars

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

May 1976

Volume

4

Issue

5

Start / End Page

297 / 310

Location

Ireland

Related Subject Headings

  • Subcellular Fractions
  • Rats
  • Organ Specificity
  • Male
  • Lysosomes
  • Luteinizing Hormone
  • Liver
  • Kinetics
  • Kidney
  • Endocrinology & Metabolism
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Ascoli, M., Liddle, R. A., & Puett, D. (1976). Renal and hepatic lysosomal catabolism of luteinizing hormone. Mol Cell Endocrinol, 4(5), 297–310. https://doi.org/10.1016/0303-7207(76)90047-2
Ascoli, M., R. A. Liddle, and D. Puett. “Renal and hepatic lysosomal catabolism of luteinizing hormone.Mol Cell Endocrinol 4, no. 5 (May 1976): 297–310. https://doi.org/10.1016/0303-7207(76)90047-2.
Ascoli M, Liddle RA, Puett D. Renal and hepatic lysosomal catabolism of luteinizing hormone. Mol Cell Endocrinol. 1976 May;4(5):297–310.
Ascoli, M., et al. “Renal and hepatic lysosomal catabolism of luteinizing hormone.Mol Cell Endocrinol, vol. 4, no. 5, May 1976, pp. 297–310. Pubmed, doi:10.1016/0303-7207(76)90047-2.
Ascoli M, Liddle RA, Puett D. Renal and hepatic lysosomal catabolism of luteinizing hormone. Mol Cell Endocrinol. 1976 May;4(5):297–310.
Journal cover image

Published In

Mol Cell Endocrinol

DOI

ISSN

0303-7207

Publication Date

May 1976

Volume

4

Issue

5

Start / End Page

297 / 310

Location

Ireland

Related Subject Headings

  • Subcellular Fractions
  • Rats
  • Organ Specificity
  • Male
  • Lysosomes
  • Luteinizing Hormone
  • Liver
  • Kinetics
  • Kidney
  • Endocrinology & Metabolism