Skip to main content

Cholecystokinin cells.

Publication ,  Journal Article
Liddle, RA
Published in: Annu Rev Physiol
1997

Cholecystokinin (CCK) is an important hormonal regulator of the digestive process. CCK cells are concentrated in the proximal small intestine, and hormone is secreted into the blood upon the ingestion of food. The physiological actions of CCK include stimulation of pancreatic secretion and gallbladder contraction, regulation of gastric emptying, and induction of satiety. Therefore, in a highly coordinated manner, CCK regulates the ingestion, digestion, and absorption of nutrients. CCK is produced by two separate cell types: endocrine cells of the small intestine and various neurons in the gastrointestinal tract and central nervous system. Accordingly, CCK can function as either a hormone or a neuropeptide. This review focuses on the physiology of the CCK cell in the intestine and, in particular, on how the CCK cell is regulated to secrete its hormone product. The effects of ingested nutrients on the CCK cell and the intracellular messenger systems involved in controlling secretion are reviewed. A summary is provided of recent studies examining the electrophysiological properties of CCK cells and newly discovered proteins that act as releasing factors for CCK, which mediate feedback pathways critical for regulated secretion in the intact organism.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

1997

Volume

59

Start / End Page

221 / 242

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Physiology
  • Peptide Mapping
  • Intestine, Small
  • Humans
  • Genes
  • Gene Expression
  • Cholecystokinin
  • Animals
  • 3208 Medical physiology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liddle, R. A. (1997). Cholecystokinin cells. Annu Rev Physiol, 59, 221–242. https://doi.org/10.1146/annurev.physiol.59.1.221
Liddle, R. A. “Cholecystokinin cells.Annu Rev Physiol 59 (1997): 221–42. https://doi.org/10.1146/annurev.physiol.59.1.221.
Liddle RA. Cholecystokinin cells. Annu Rev Physiol. 1997;59:221–42.
Liddle, R. A. “Cholecystokinin cells.Annu Rev Physiol, vol. 59, 1997, pp. 221–42. Pubmed, doi:10.1146/annurev.physiol.59.1.221.
Liddle RA. Cholecystokinin cells. Annu Rev Physiol. 1997;59:221–242.

Published In

Annu Rev Physiol

DOI

ISSN

0066-4278

Publication Date

1997

Volume

59

Start / End Page

221 / 242

Location

United States

Related Subject Headings

  • Structure-Activity Relationship
  • Physiology
  • Peptide Mapping
  • Intestine, Small
  • Humans
  • Genes
  • Gene Expression
  • Cholecystokinin
  • Animals
  • 3208 Medical physiology