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Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation.

Publication ,  Journal Article
Baron, PW; Heneghan, MA; Suhocki, PV; Nuckols, JD; Tuttle-Newhall, JE; Howell, DN; Clavien, PA
Published in: Liver Transpl
January 2001

Biliary complications after orthotopic liver transplantation (OLT) lead to considerable morbidity and occasional mortality after surgery. Bile duct strictures secondary to localized lymphoproliferative disorder of the porta hepatis is rare, with only 12 cases reported in the English literature. Posttransplant lymphoproliferative disorder develops in up to 9% of liver allograft recipients. We describe 2 adult patients who developed Epstein-Barr virus-associated localized B-cell lymphoma of donor-tissue origin confined to the porta hepatis 3 and 5 months after OLT. Both patients were administered cyclosporine (CyA) and prednisone as primary immunosuppression. One patient was administered basiliximab as induction therapy. Neither patient had CyA trough levels greater than 250 ng/mL. Both patients were treated with a hepatojejunostomy, 75% reduction in immunosuppression therapy, and acyclovir. One patient had complete involution of the tumor, and the second patient had an 80% reduction of the tumor at the 2-year follow-up visit. This report illustrates the need to consider localized lymphoma post-OLT as a cause of obstructive jaundice even within the first 6 months after surgery. Aggressive reduction of immunosuppression in conjunction with acyclovir remains a highly effective therapy.

Duke Scholars

Published In

Liver Transpl

DOI

ISSN

1527-6465

Publication Date

January 2001

Volume

7

Issue

1

Start / End Page

62 / 67

Location

United States

Related Subject Headings

  • Tissue Donors
  • Surgery
  • Reoperation
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Liver Transplantation
  • Immunosuppressive Agents
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Baron, P. W., Heneghan, M. A., Suhocki, P. V., Nuckols, J. D., Tuttle-Newhall, J. E., Howell, D. N., & Clavien, P. A. (2001). Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation. Liver Transpl, 7(1), 62–67. https://doi.org/10.1053/jlts.2001.20781
Baron, P. W., M. A. Heneghan, P. V. Suhocki, J. D. Nuckols, J. E. Tuttle-Newhall, D. N. Howell, and P. A. Clavien. “Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation.Liver Transpl 7, no. 1 (January 2001): 62–67. https://doi.org/10.1053/jlts.2001.20781.
Baron PW, Heneghan MA, Suhocki PV, Nuckols JD, Tuttle-Newhall JE, Howell DN, et al. Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation. Liver Transpl. 2001 Jan;7(1):62–7.
Baron, P. W., et al. “Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation.Liver Transpl, vol. 7, no. 1, Jan. 2001, pp. 62–67. Pubmed, doi:10.1053/jlts.2001.20781.
Baron PW, Heneghan MA, Suhocki PV, Nuckols JD, Tuttle-Newhall JE, Howell DN, Clavien PA. Biliary stricture secondary to donor B-cell lymphoma after orthotopic liver transplantation. Liver Transpl. 2001 Jan;7(1):62–67.
Journal cover image

Published In

Liver Transpl

DOI

ISSN

1527-6465

Publication Date

January 2001

Volume

7

Issue

1

Start / End Page

62 / 67

Location

United States

Related Subject Headings

  • Tissue Donors
  • Surgery
  • Reoperation
  • Middle Aged
  • Male
  • Lymphoma, B-Cell
  • Liver Transplantation
  • Immunosuppressive Agents
  • Humans
  • Female