The role of mast cells in host defense and their subversion by bacterial pathogens.
Publication
, Journal Article
Féger, F; Varadaradjalou, S; Gao, Z; Abraham, SN; Arock, M
Published in: Trends Immunol
March 2002
Mast cells (MCs) play a prominent role in the early immune response to invading pathogenic bacteria. This newly discovered role for MCs involves the release of chemoattractants that recruit neutrophils and the direct phagocytosis and killing of opsonized bacteria. Whereas these activities are clearly beneficial to the host, certain pathogens have evolved mechanisms to evoke anomalous MC responses to the detriment of the host. These include evoking phagocytosis without killing of unopsonized bacteria and the production of toxins that corrupt the release of mediators by MCs. Elucidating how pathogens subvert the activities of MCs could provide clues to limiting the pathological activities of these cells during infectious diseases.
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Published In
Trends Immunol
DOI
ISSN
1471-4906
Publication Date
March 2002
Volume
23
Issue
3
Start / End Page
151 / 158
Location
England
Related Subject Headings
- Models, Immunological
- Mice
- Mast Cells
- Immunology
- Humans
- Cell Culture Techniques
- Bacterial Infections
- Bacteria
- Animals
- 3204 Immunology
Citation
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Chicago
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MLA
NLM
Féger, F., Varadaradjalou, S., Gao, Z., Abraham, S. N., & Arock, M. (2002). The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol, 23(3), 151–158. https://doi.org/10.1016/s1471-4906(01)02156-1
Féger, Frédéric, Sonia Varadaradjalou, Zhimin Gao, Soman N. Abraham, and Michel Arock. “The role of mast cells in host defense and their subversion by bacterial pathogens.” Trends Immunol 23, no. 3 (March 2002): 151–58. https://doi.org/10.1016/s1471-4906(01)02156-1.
Féger F, Varadaradjalou S, Gao Z, Abraham SN, Arock M. The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol. 2002 Mar;23(3):151–8.
Féger, Frédéric, et al. “The role of mast cells in host defense and their subversion by bacterial pathogens.” Trends Immunol, vol. 23, no. 3, Mar. 2002, pp. 151–58. Pubmed, doi:10.1016/s1471-4906(01)02156-1.
Féger F, Varadaradjalou S, Gao Z, Abraham SN, Arock M. The role of mast cells in host defense and their subversion by bacterial pathogens. Trends Immunol. 2002 Mar;23(3):151–158.
Published In
Trends Immunol
DOI
ISSN
1471-4906
Publication Date
March 2002
Volume
23
Issue
3
Start / End Page
151 / 158
Location
England
Related Subject Headings
- Models, Immunological
- Mice
- Mast Cells
- Immunology
- Humans
- Cell Culture Techniques
- Bacterial Infections
- Bacteria
- Animals
- 3204 Immunology