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Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.

Publication ,  Journal Article
McCusker, JH; Clemons, KV; Stevens, DA; Davis, RW
Published in: Genetics
April 1994

Saccharomyces cerevisiae isolates from human patients have been genetically analyzed. Some of the characteristics of these isolates are very different from laboratory and industrial strains of S. cerevisiae and, for this reason, stringent genetic tests have been used to confirm their identity as S. cerevisiae. Most of these clinical isolates are able to grow at 42 degrees, a temperature that completely inhibits the growth of most other S. cerevisiae strains. This property can be considered a virulence trait and may help explain the presence of these isolates in human hosts. The ability to grow at 42 degrees is shown to be polygenic with primarily additive effects between loci. S. cerevisiae will be a useful model for the evolution and genetic analysis of fungal virulence and the study of polygenic traits.

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Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

April 1994

Volume

136

Issue

4

Start / End Page

1261 / 1269

Location

United States

Related Subject Headings

  • Virulence
  • Temperature
  • Saccharomyces cerevisiae
  • Humans
  • Developmental Biology
  • Crosses, Genetic
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics
 

Citation

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McCusker, J. H., Clemons, K. V., Stevens, D. A., & Davis, R. W. (1994). Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. Genetics, 136(4), 1261–1269. https://doi.org/10.1093/genetics/136.4.1261
McCusker, J. H., K. V. Clemons, D. A. Stevens, and R. W. Davis. “Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.Genetics 136, no. 4 (April 1994): 1261–69. https://doi.org/10.1093/genetics/136.4.1261.
McCusker JH, Clemons KV, Stevens DA, Davis RW. Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. Genetics. 1994 Apr;136(4):1261–9.
McCusker, J. H., et al. “Genetic characterization of pathogenic Saccharomyces cerevisiae isolates.Genetics, vol. 136, no. 4, Apr. 1994, pp. 1261–69. Pubmed, doi:10.1093/genetics/136.4.1261.
McCusker JH, Clemons KV, Stevens DA, Davis RW. Genetic characterization of pathogenic Saccharomyces cerevisiae isolates. Genetics. 1994 Apr;136(4):1261–1269.

Published In

Genetics

DOI

ISSN

0016-6731

Publication Date

April 1994

Volume

136

Issue

4

Start / End Page

1261 / 1269

Location

United States

Related Subject Headings

  • Virulence
  • Temperature
  • Saccharomyces cerevisiae
  • Humans
  • Developmental Biology
  • Crosses, Genetic
  • 3105 Genetics
  • 3101 Biochemistry and cell biology
  • 0604 Genetics