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The pterin of the molybdenum cofactor.

Publication ,  Journal Article
Rajagopalan, KV; Johnson, JL; Hainline, BE
Published in: Fed Proc
July 1982

The molybdenum cofactor common to a variety of molybdoenzymes has been shown to contain a novel pterin. The pterin has been isolated from sulfite oxidase from several sources, xanthine-oxidizing enzymes from milk and chicken liver, and nitrate reductase of Chlorella vulgaris after denaturation of the proteins in the presence of I2. Investigation of the anionic nature of the isolated pterin has revealed that it is a monophosphate ester susceptible to cleavage by alkaline phosphatase. Quantitative analyses have shown that one molecule of the pterin phosphate is associated with each molybdenum atom in sulfite oxidase. Studies to date have shown that the pterin is present in a reduced form in sulfite oxidase and xanthine dehydrogenase, and that in situ oxidation of the pterin leads to inactivation of sulfite oxidase.

Duke Scholars

Published In

Fed Proc

ISSN

0014-9446

Publication Date

July 1982

Volume

41

Issue

9

Start / End Page

2608 / 2612

Location

United States

Related Subject Headings

  • Xanthine Dehydrogenase
  • Pterins
  • Oxidoreductases Acting on Sulfur Group Donors
  • Oxidation-Reduction
  • Nitrates
  • Molybdoferredoxin
  • Molybdenum
  • Milk
  • Liver
  • Coenzymes
 

Citation

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Rajagopalan, K. V., Johnson, J. L., & Hainline, B. E. (1982). The pterin of the molybdenum cofactor. Fed Proc, 41(9), 2608–2612.
Rajagopalan, K. V., J. L. Johnson, and B. E. Hainline. “The pterin of the molybdenum cofactor.Fed Proc 41, no. 9 (July 1982): 2608–12.
Rajagopalan KV, Johnson JL, Hainline BE. The pterin of the molybdenum cofactor. Fed Proc. 1982 Jul;41(9):2608–12.
Rajagopalan, K. V., et al. “The pterin of the molybdenum cofactor.Fed Proc, vol. 41, no. 9, July 1982, pp. 2608–12.
Rajagopalan KV, Johnson JL, Hainline BE. The pterin of the molybdenum cofactor. Fed Proc. 1982 Jul;41(9):2608–2612.

Published In

Fed Proc

ISSN

0014-9446

Publication Date

July 1982

Volume

41

Issue

9

Start / End Page

2608 / 2612

Location

United States

Related Subject Headings

  • Xanthine Dehydrogenase
  • Pterins
  • Oxidoreductases Acting on Sulfur Group Donors
  • Oxidation-Reduction
  • Nitrates
  • Molybdoferredoxin
  • Molybdenum
  • Milk
  • Liver
  • Coenzymes