Skip to main content

Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport.

Publication ,  Journal Article
Bradford, W; Allen, D; Shelburne, J; Spock, A
Published in: Pediatr Pathol
1983

Few ultrastructural observations of hepatic parenchymal cells in cystic fibrosis (CF) have appeared in the literature. Utilizing a unique opportunity to examine freshly fixed hepatic tissue by transmission electron microscopy, we studied 12 patients dying with CF at Duke Hospital from 1979 to 1981 in order to identify possible abnormalities of intracellular architecture. The major findings include (1) intracellular fatty vacuoles, (2) distended bile ductules and bile ducts containing increased cellular debris, (3) profiles of distended rough endoplasmic reticulum containing material of medium electron density, and (4) membrane-bound deposits of electron-lucent material containing electron-dense cores resembling mucus. We suggest that the material seen within the cytocavitary network reflects a derangement of intracellular transport.

Duke Scholars

Published In

Pediatr Pathol

DOI

ISSN

0277-0938

Publication Date

1983

Volume

1

Issue

3

Start / End Page

269 / 279

Location

United States

Related Subject Headings

  • Microscopy, Electron
  • Liver
  • Humans
  • Endoplasmic Reticulum
  • Cystic Fibrosis
  • Child
  • Biological Transport
  • Bile Ducts, Intrahepatic
  • Adult
  • Adolescent
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bradford, W., Allen, D., Shelburne, J., & Spock, A. (1983). Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport. Pediatr Pathol, 1(3), 269–279. https://doi.org/10.3109/15513818309040664
Bradford, W., D. Allen, J. Shelburne, and A. Spock. “Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport.Pediatr Pathol 1, no. 3 (1983): 269–79. https://doi.org/10.3109/15513818309040664.
Bradford W, Allen D, Shelburne J, Spock A. Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport. Pediatr Pathol. 1983;1(3):269–79.
Bradford, W., et al. “Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport.Pediatr Pathol, vol. 1, no. 3, 1983, pp. 269–79. Pubmed, doi:10.3109/15513818309040664.
Bradford W, Allen D, Shelburne J, Spock A. Hepatic parenchymal cells in cystic fibrosis: ultrastructural evidence for abnormal intracellular transport. Pediatr Pathol. 1983;1(3):269–279.

Published In

Pediatr Pathol

DOI

ISSN

0277-0938

Publication Date

1983

Volume

1

Issue

3

Start / End Page

269 / 279

Location

United States

Related Subject Headings

  • Microscopy, Electron
  • Liver
  • Humans
  • Endoplasmic Reticulum
  • Cystic Fibrosis
  • Child
  • Biological Transport
  • Bile Ducts, Intrahepatic
  • Adult
  • Adolescent