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Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).

Publication ,  Journal Article
Ramakrishnan, L; Valdivia, RH; McKerrow, JH; Falkow, S
Published in: Infect Immun
February 1997

Mycobacterium marinum grows at an optimal temperature of 33 degrees C, far lower than that for M. tuberculosis. Consequently, M. marinum infection of mammals is restricted largely to the cooler surfaces of the body, such as the extremities, but it causes a systemic infection in a large number of poikilothermic animals. Here, we describe a laboratory animal model for M. marinum disease in the leopard frog (Rana pipiens), a natural host species. M. marinum causes a chronic granulomatous, nonlethal disease in immunocompetent frogs. Immunosuppression of the frogs with hydrocortisone results in an acute, fulminant, lethal disease. This animal model, in which a spectrum of tuberculosis-like disease can be produced, will be useful for the dissection of the genetic basis of mycobacterial pathogenesis.

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Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

February 1997

Volume

65

Issue

2

Start / End Page

767 / 773

Location

United States

Related Subject Headings

  • Uracil
  • Rana pipiens
  • Nontuberculous Mycobacteria
  • Mycobacterium Infections, Nontuberculous
  • Mutation
  • Microbiology
  • Male
  • Injections, Intraperitoneal
  • Hydrocortisone
  • Granuloma
 

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Ramakrishnan, L., Valdivia, R. H., McKerrow, J. H., & Falkow, S. (1997). Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun, 65(2), 767–773. https://doi.org/10.1128/iai.65.2.767-773.1997
Ramakrishnan, L., R. H. Valdivia, J. H. McKerrow, and S. Falkow. “Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).Infect Immun 65, no. 2 (February 1997): 767–73. https://doi.org/10.1128/iai.65.2.767-773.1997.
Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb;65(2):767–73.
Ramakrishnan, L., et al. “Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens).Infect Immun, vol. 65, no. 2, Feb. 1997, pp. 767–73. Pubmed, doi:10.1128/iai.65.2.767-773.1997.
Ramakrishnan L, Valdivia RH, McKerrow JH, Falkow S. Mycobacterium marinum causes both long-term subclinical infection and acute disease in the leopard frog (Rana pipiens). Infect Immun. 1997 Feb;65(2):767–773.

Published In

Infect Immun

DOI

ISSN

0019-9567

Publication Date

February 1997

Volume

65

Issue

2

Start / End Page

767 / 773

Location

United States

Related Subject Headings

  • Uracil
  • Rana pipiens
  • Nontuberculous Mycobacteria
  • Mycobacterium Infections, Nontuberculous
  • Mutation
  • Microbiology
  • Male
  • Injections, Intraperitoneal
  • Hydrocortisone
  • Granuloma