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Features of benign granular cell tumor on fine needle aspiration.

Publication ,  Journal Article
Liu, K; Madden, JF; Olatidoye, BA; Dodd, LG
Published in: Acta Cytol
1999

OBJECTIVE: To describe the cytomorphologic features of benign granular cell tumor (GCT) on fine needle aspiration (FNA) biopsy and discuss the differential diagnosis. STUDY DESIGN: We reviewed three fine needle aspirates of surgically confirmed benign GCT. Immunocytochemical staining for S-100 was performed on the aspirate smear in one case. RESULTS: Two GCT were thigh lesions, where lipoma and fibromatosis were the leading clinical diagnosis, and the third was a breast mass clinically suspected to be a fibroadenoma. All FNA specimens were highly cellular and composed of fairly uniform cells with eccentric, round-to-slightly oval nuclei and abundant, finely granular cytoplasm. The cells were fragile, with stripped nuclei in a background of finely granular material. Occasional cells with nuclear pleomorphism and small-but-conspicuous nucleoli were identified. There was no evidence of necrosis or mitotic activity. Rare intranuclear cytoplasmic inclusions were identified in two cases. The granular cells were immunoreactive for S-100 in the case studied. CONCLUSION: Benign GCT has a distinctive cytomorphologic appearance that permits its diagnosis on FNA. High cellularity, occasional cells with nuclear pleomorphism and prominent nucleoli are features that can be present in benign GCT. Mitotic figures and necrosis should be identified before a diagnosis of malignancy is rendered.

Duke Scholars

Published In

Acta Cytol

DOI

ISSN

0001-5547

Publication Date

1999

Volume

43

Issue

4

Start / End Page

552 / 557

Location

Switzerland

Related Subject Headings

  • Soft Tissue Neoplasms
  • Pathology
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Granular Cell Tumor
  • Female
  • Diagnosis, Differential
  • Breast Neoplasms
  • Biopsy, Needle
 

Citation

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ICMJE
MLA
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Liu, K., Madden, J. F., Olatidoye, B. A., & Dodd, L. G. (1999). Features of benign granular cell tumor on fine needle aspiration. Acta Cytol, 43(4), 552–557. https://doi.org/10.1159/000331146
Liu, K., J. F. Madden, B. A. Olatidoye, and L. G. Dodd. “Features of benign granular cell tumor on fine needle aspiration.Acta Cytol 43, no. 4 (1999): 552–57. https://doi.org/10.1159/000331146.
Liu K, Madden JF, Olatidoye BA, Dodd LG. Features of benign granular cell tumor on fine needle aspiration. Acta Cytol. 1999;43(4):552–7.
Liu, K., et al. “Features of benign granular cell tumor on fine needle aspiration.Acta Cytol, vol. 43, no. 4, 1999, pp. 552–57. Pubmed, doi:10.1159/000331146.
Liu K, Madden JF, Olatidoye BA, Dodd LG. Features of benign granular cell tumor on fine needle aspiration. Acta Cytol. 1999;43(4):552–557.
Journal cover image

Published In

Acta Cytol

DOI

ISSN

0001-5547

Publication Date

1999

Volume

43

Issue

4

Start / End Page

552 / 557

Location

Switzerland

Related Subject Headings

  • Soft Tissue Neoplasms
  • Pathology
  • Middle Aged
  • Immunohistochemistry
  • Humans
  • Granular Cell Tumor
  • Female
  • Diagnosis, Differential
  • Breast Neoplasms
  • Biopsy, Needle