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Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast.

Publication ,  Journal Article
Layfield, LJ; Dodd, LG
Published in: Diagn Cytopathol
September 1996

Failure to diagnose breast carcinoma by fine-needle aspiration (FNA) is a major obstacle to expanded use of that technique. While the majority of false negative diagnoses are due to inadequate sampling and insufficient specimens, a significant minority of false negative cases result from inaccurate interpretation of adequate material. Low grade carcinomas including lobular, tubular, low grade adenosquamous, and papillary carcinomas appear to account for many of these diagnostic errors. Careful attention to nuclear detail, monomorphism of cell population and the presence of neoplastic cells with retained cytoplasm should allow the recognition of the majority of these neoplasms as malignant by cytologic examination.

Duke Scholars

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

September 1996

Volume

15

Issue

3

Start / End Page

250 / 259

Location

United States

Related Subject Headings

  • Pathology
  • Humans
  • Hemangiosarcoma
  • False Negative Reactions
  • Carcinoma, Signet Ring Cell
  • Carcinoma, Papillary
  • Carcinoma, Lobular
  • Carcinoma, Adenosquamous
  • Breast Neoplasms
  • Biopsy, Needle
 

Citation

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ICMJE
MLA
NLM
Layfield, L. J., & Dodd, L. G. (1996). Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast. Diagn Cytopathol, 15(3), 250–259. https://doi.org/10.1002/(SICI)1097-0339(199609)15:3<250::AID-DC15>3.0.CO;2-F
Layfield, L. J., and L. G. Dodd. “Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast.Diagn Cytopathol 15, no. 3 (September 1996): 250–59. https://doi.org/10.1002/(SICI)1097-0339(199609)15:3<250::AID-DC15>3.0.CO;2-F.
Layfield, L. J., and L. G. Dodd. “Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast.Diagn Cytopathol, vol. 15, no. 3, Sept. 1996, pp. 250–59. Pubmed, doi:10.1002/(SICI)1097-0339(199609)15:3<250::AID-DC15>3.0.CO;2-F.
Journal cover image

Published In

Diagn Cytopathol

DOI

ISSN

8755-1039

Publication Date

September 1996

Volume

15

Issue

3

Start / End Page

250 / 259

Location

United States

Related Subject Headings

  • Pathology
  • Humans
  • Hemangiosarcoma
  • False Negative Reactions
  • Carcinoma, Signet Ring Cell
  • Carcinoma, Papillary
  • Carcinoma, Lobular
  • Carcinoma, Adenosquamous
  • Breast Neoplasms
  • Biopsy, Needle