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Rocky mountain spotted fever: hepatic lesions in childhood cases.

Publication ,  Journal Article
Jackson, MD; Kirkman, C; Bradford, WD; Walker, DH
Published in: Pediatr Pathol
1986

We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases.

Duke Scholars

Published In

Pediatr Pathol

DOI

ISSN

0277-0938

Publication Date

1986

Volume

5

Issue

3-4

Start / End Page

379 / 388

Location

United States

Related Subject Headings

  • Rocky Mountain Spotted Fever
  • Male
  • Liver
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Child, Preschool
  • Child
  • Adolescent
 

Citation

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Chicago
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MLA
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Jackson, M. D., Kirkman, C., Bradford, W. D., & Walker, D. H. (1986). Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol, 5(3–4), 379–388. https://doi.org/10.3109/15513818609068864
Jackson, M. D., C. Kirkman, W. D. Bradford, and D. H. Walker. “Rocky mountain spotted fever: hepatic lesions in childhood cases.Pediatr Pathol 5, no. 3–4 (1986): 379–88. https://doi.org/10.3109/15513818609068864.
Jackson MD, Kirkman C, Bradford WD, Walker DH. Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol. 1986;5(3–4):379–88.
Jackson, M. D., et al. “Rocky mountain spotted fever: hepatic lesions in childhood cases.Pediatr Pathol, vol. 5, no. 3–4, 1986, pp. 379–88. Pubmed, doi:10.3109/15513818609068864.
Jackson MD, Kirkman C, Bradford WD, Walker DH. Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol. 1986;5(3–4):379–388.

Published In

Pediatr Pathol

DOI

ISSN

0277-0938

Publication Date

1986

Volume

5

Issue

3-4

Start / End Page

379 / 388

Location

United States

Related Subject Headings

  • Rocky Mountain Spotted Fever
  • Male
  • Liver
  • Humans
  • Fluorescent Antibody Technique
  • Female
  • Child, Preschool
  • Child
  • Adolescent