Rocky mountain spotted fever: hepatic lesions in childhood cases.
Publication
, Journal Article
Jackson, MD; Kirkman, C; Bradford, WD; Walker, DH
Published in: Pediatr Pathol
1986
We studied 16 fatal childhood cases of Rocky Mountain spotted fever (RMSF). Hepatic histologic lesions with statistically significant differences from age- and sex-matched controls were portal triaditis consisting of polymorphonuclear leukocytes and large mononuclear cells, portal vasculitis, sinusoidal leukocytosis, erythrophagocytosis by Kupffer cells, and gross hepatic weight. Hepatocellular necrosis, cholestasis, and congestion were not more frequent in RMSF than in controls. Using immunofluorescence microscopy, we were able to demonstrate rickettsial organisms in portal blood vessels and sinusoidal lining cells of 7 cases.
Duke Scholars
Published In
Pediatr Pathol
DOI
ISSN
0277-0938
Publication Date
1986
Volume
5
Issue
3-4
Start / End Page
379 / 388
Location
United States
Related Subject Headings
- Rocky Mountain Spotted Fever
- Male
- Liver
- Humans
- Fluorescent Antibody Technique
- Female
- Child, Preschool
- Child
- Adolescent
Citation
APA
Chicago
ICMJE
MLA
NLM
Jackson, M. D., Kirkman, C., Bradford, W. D., & Walker, D. H. (1986). Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol, 5(3–4), 379–388. https://doi.org/10.3109/15513818609068864
Jackson, M. D., C. Kirkman, W. D. Bradford, and D. H. Walker. “Rocky mountain spotted fever: hepatic lesions in childhood cases.” Pediatr Pathol 5, no. 3–4 (1986): 379–88. https://doi.org/10.3109/15513818609068864.
Jackson MD, Kirkman C, Bradford WD, Walker DH. Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol. 1986;5(3–4):379–88.
Jackson, M. D., et al. “Rocky mountain spotted fever: hepatic lesions in childhood cases.” Pediatr Pathol, vol. 5, no. 3–4, 1986, pp. 379–88. Pubmed, doi:10.3109/15513818609068864.
Jackson MD, Kirkman C, Bradford WD, Walker DH. Rocky mountain spotted fever: hepatic lesions in childhood cases. Pediatr Pathol. 1986;5(3–4):379–388.
Published In
Pediatr Pathol
DOI
ISSN
0277-0938
Publication Date
1986
Volume
5
Issue
3-4
Start / End Page
379 / 388
Location
United States
Related Subject Headings
- Rocky Mountain Spotted Fever
- Male
- Liver
- Humans
- Fluorescent Antibody Technique
- Female
- Child, Preschool
- Child
- Adolescent