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Conserved cAMP signaling cascades regulate fungal development and virulence.

Publication ,  Journal Article
D'Souza, CA; Heitman, J
Published in: FEMS Microbiol Rev
May 2001

Two well characterized signal transduction cascades regulating fungal development and virulence are the MAP kinase and cAMP signaling cascades. Here we review the current state of knowledge on cAMP signaling cascades in fungi. While the processes regulated by cAMP signaling in fungi are as diverse as the fungi themselves, the components involved in signal transduction are remarkably conserved. Fungal cAMP signaling cascades are also quite versatile, which is apparent from the differential regulation of similar biological processes. In this review we compare and contrast cAMP signaling pathways that regulate development in the budding yeast Saccharomyces cerevisiae, the fission yeast Schizosaccharomyces pombe, and differentiation and virulence in the human pathogen Cryptococcus neoformans and the plant pathogen Ustilago maydis. We also present examples of interaction between the cAMP and MAP kinase signaling cascades in the regulation of fungal development and virulence.

Duke Scholars

Published In

FEMS Microbiol Rev

DOI

ISSN

0168-6445

Publication Date

May 2001

Volume

25

Issue

3

Start / End Page

349 / 364

Location

England

Related Subject Headings

  • Virulence
  • Ustilago
  • Signal Transduction
  • Schizosaccharomyces
  • Saccharomyces cerevisiae
  • Molecular Sequence Data
  • Microbiology
  • MAP Kinase Signaling System
  • Gene Expression Regulation, Fungal
  • Fungi
 

Citation

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D’Souza, C. A., & Heitman, J. (2001). Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev, 25(3), 349–364. https://doi.org/10.1111/j.1574-6976.2001.tb00582.x
D’Souza, C. A., and J. Heitman. “Conserved cAMP signaling cascades regulate fungal development and virulence.FEMS Microbiol Rev 25, no. 3 (May 2001): 349–64. https://doi.org/10.1111/j.1574-6976.2001.tb00582.x.
D’Souza CA, Heitman J. Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev. 2001 May;25(3):349–64.
D’Souza, C. A., and J. Heitman. “Conserved cAMP signaling cascades regulate fungal development and virulence.FEMS Microbiol Rev, vol. 25, no. 3, May 2001, pp. 349–64. Pubmed, doi:10.1111/j.1574-6976.2001.tb00582.x.
D’Souza CA, Heitman J. Conserved cAMP signaling cascades regulate fungal development and virulence. FEMS Microbiol Rev. 2001 May;25(3):349–364.
Journal cover image

Published In

FEMS Microbiol Rev

DOI

ISSN

0168-6445

Publication Date

May 2001

Volume

25

Issue

3

Start / End Page

349 / 364

Location

England

Related Subject Headings

  • Virulence
  • Ustilago
  • Signal Transduction
  • Schizosaccharomyces
  • Saccharomyces cerevisiae
  • Molecular Sequence Data
  • Microbiology
  • MAP Kinase Signaling System
  • Gene Expression Regulation, Fungal
  • Fungi