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Clinical importance of "breakthrough" bacteremia.

Publication ,  Journal Article
Weinstein, MP; Reller, LB
Published in: Am J Med
February 1984

Fifty-one episodes of bacteremia and a single episode of fungemia occurred during treatment with seemingly adequate doses of appropriate antibiotics. Clinical findings in these "breakthrough" bacteremias and fungemia were compared with those in 448 non-breakthrough episodes. Breakthrough was more likely to be caused by facultative or aerobic gram-negative rods (e.g., Enterobacteriaceae and Pseudomonas species) than by anaerobes. Of the underlying conditions examined, immunosuppressive doses of glucocorticosteroids, diabetes mellitus, and moderate renal failure were significantly more frequent in patients with breakthrough. A significant association was also observed between an intra-abdominal primary focus of infection (abscesses, biliary tract or bowel infections) and the occurrence of breakthrough. Mortality in breakthrough bacteremia was 61 percent compared with 40 percent in non-breakthrough episodes. The phenomenon of breakthrough bacteremia shows the potential limitations of antibiotic therapy alone.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

February 1984

Volume

76

Issue

2

Start / End Page

175 / 180

Location

United States

Related Subject Headings

  • Sepsis
  • Risk
  • Mycoses
  • Middle Aged
  • Male
  • Humans
  • Gram-Negative Bacteria
  • General & Internal Medicine
  • Anti-Bacterial Agents
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Weinstein, M. P., & Reller, L. B. (1984). Clinical importance of "breakthrough" bacteremia. Am J Med, 76(2), 175–180. https://doi.org/10.1016/0002-9343(84)90770-8
Weinstein, M. P., and L. B. Reller. “Clinical importance of "breakthrough" bacteremia.Am J Med 76, no. 2 (February 1984): 175–80. https://doi.org/10.1016/0002-9343(84)90770-8.
Weinstein MP, Reller LB. Clinical importance of "breakthrough" bacteremia. Am J Med. 1984 Feb;76(2):175–80.
Weinstein, M. P., and L. B. Reller. “Clinical importance of "breakthrough" bacteremia.Am J Med, vol. 76, no. 2, Feb. 1984, pp. 175–80. Pubmed, doi:10.1016/0002-9343(84)90770-8.
Weinstein MP, Reller LB. Clinical importance of "breakthrough" bacteremia. Am J Med. 1984 Feb;76(2):175–180.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

February 1984

Volume

76

Issue

2

Start / End Page

175 / 180

Location

United States

Related Subject Headings

  • Sepsis
  • Risk
  • Mycoses
  • Middle Aged
  • Male
  • Humans
  • Gram-Negative Bacteria
  • General & Internal Medicine
  • Anti-Bacterial Agents
  • Aged