Correlation of serum bactericidal activity with antimicrobial agent level and minimal bactericidal concentration.
Few data are available to show how serum dilution test results correlate with results of antimicrobial assays and determinations of minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs). Serum dilution tests were performed for 65 patients with bacteremia from serious infections. Assays for antimicrobial agent levels and determinations fo MICs and MBCs against the infecting organisms were performed simultaneously. Mueller-Hinton broth and Mueller-Hinton broth supplemented with Ca++, Mg++, and pooled human serum were compared as diluents for the serum either medium yielded positive correlations, better correlations were found between measured and expected serum bactericidal activities when both ther serum dilution test dilutions and the MIC and MBC determinations were done in the supplemented MHB-human serum solution.
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Related Subject Headings
- Sepsis
- Microbiology
- Humans
- Bacteriological Techniques
- Bacteria
- Anti-Bacterial Agents
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Sepsis
- Microbiology
- Humans
- Bacteriological Techniques
- Bacteria
- Anti-Bacterial Agents
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences