Skip to main content

Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study.

Publication ,  Journal Article
Gavan, TL; Jones, RN; Barry, AL; Fuchs, PC; Gerlach, EH; Matsen, JM; Reller, LB; Thornsberry, C; Thrupp, LD
Published in: J Clin Microbiol
July 1981

A multilaboratory in vitro study was carried out to determine disk diffusion susceptibility testing quality control limits for two new semisynthetic penicillins, mezlocillin and piperacillin. Existing limits for carbenicillin and ampicillin were reevaluated. Multiple tests (which followed standards set by the National Committee for Clinical Laboratory Standards ASM-2 revised) were performed in nine laboratories by different technologists using disks and Mueller-Hinton agar from different manufacturers. Clinically significant differences between disks produced by different manufacturers were not noted. Inhibitory zone diameter measurements from all laboratories were analyzed, and upper and lower control limits were established by using the overall median +/-0.5 the median range of the individual laboratory measurements as determining parameters. Close agreement of the data in this study with the results of national proficiency testing and quality control programs for ampicillin and carbenicillin supports the validity of our approach to making initial recommendations for quality control guidelines for new antimicrobial agents.

Duke Scholars

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

July 1981

Volume

14

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Quality Control
  • Pseudomonas aeruginosa
  • Piperacillin
  • Penicillins
  • Microbiology
  • Microbial Sensitivity Tests
  • Mezlocillin
  • Escherichia coli
  • Carbenicillin
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gavan, T. L., Jones, R. N., Barry, A. L., Fuchs, P. C., Gerlach, E. H., Matsen, J. M., … Thrupp, L. D. (1981). Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study. J Clin Microbiol, 14(1), 67–72. https://doi.org/10.1128/jcm.14.1.67-72.1981
Gavan, T. L., R. N. Jones, A. L. Barry, P. C. Fuchs, E. H. Gerlach, J. M. Matsen, L. B. Reller, C. Thornsberry, and L. D. Thrupp. “Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study.J Clin Microbiol 14, no. 1 (July 1981): 67–72. https://doi.org/10.1128/jcm.14.1.67-72.1981.
Gavan TL, Jones RN, Barry AL, Fuchs PC, Gerlach EH, Matsen JM, et al. Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study. J Clin Microbiol. 1981 Jul;14(1):67–72.
Gavan, T. L., et al. “Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study.J Clin Microbiol, vol. 14, no. 1, July 1981, pp. 67–72. Pubmed, doi:10.1128/jcm.14.1.67-72.1981.
Gavan TL, Jones RN, Barry AL, Fuchs PC, Gerlach EH, Matsen JM, Reller LB, Thornsberry C, Thrupp LD. Quality control limits for ampicillin, carbenicillin, mezlocillin, and piperacillin disk diffusion susceptibility tests: a collaborative study. J Clin Microbiol. 1981 Jul;14(1):67–72.

Published In

J Clin Microbiol

DOI

ISSN

0095-1137

Publication Date

July 1981

Volume

14

Issue

1

Start / End Page

67 / 72

Location

United States

Related Subject Headings

  • Staphylococcus aureus
  • Quality Control
  • Pseudomonas aeruginosa
  • Piperacillin
  • Penicillins
  • Microbiology
  • Microbial Sensitivity Tests
  • Mezlocillin
  • Escherichia coli
  • Carbenicillin