Tumor oxygenation: a matter of supply and demand.
Publication
, Journal Article
Gulledge, CJ; Dewhirst, MW
Published in: Anticancer Res
1996
Development of new approaches to ameliorate tumor hypoxia may require understanding of the relative importance of supply vs. demand. On the demand side, abnormalities in energy metabolism are known to be related to defects in regulation of respiratory enzymes, combined with high demand for energy caused by cell proliferation. On the supply side deficiencies in efficiency of nutrient supply, such as low vascular density and uneven vascular distribution appear to play important roles. In theoretical simulations based on actual in vivo data, however, modulation of oxygen consumption is much more efficient in affecting oxygen transport than modification of delivery.
Duke Scholars
Published In
Anticancer Res
ISSN
0250-7005
Publication Date
1996
Volume
16
Issue
2
Start / End Page
741 / 749
Location
Greece
Related Subject Headings
- Regional Blood Flow
- Oxygen Consumption
- Oncology & Carcinogenesis
- Neoplasms
- Mitochondria
- Humans
- Glucose
- Energy Metabolism
- Cell Hypoxia
- Anemia
Citation
APA
Chicago
ICMJE
MLA
NLM
Gulledge, C. J., & Dewhirst, M. W. (1996). Tumor oxygenation: a matter of supply and demand. Anticancer Res, 16(2), 741–749.
Gulledge, C. J., and M. W. Dewhirst. “Tumor oxygenation: a matter of supply and demand.” Anticancer Res 16, no. 2 (1996): 741–49.
Gulledge CJ, Dewhirst MW. Tumor oxygenation: a matter of supply and demand. Anticancer Res. 1996;16(2):741–9.
Gulledge, C. J., and M. W. Dewhirst. “Tumor oxygenation: a matter of supply and demand.” Anticancer Res, vol. 16, no. 2, 1996, pp. 741–49.
Gulledge CJ, Dewhirst MW. Tumor oxygenation: a matter of supply and demand. Anticancer Res. 1996;16(2):741–749.
Published In
Anticancer Res
ISSN
0250-7005
Publication Date
1996
Volume
16
Issue
2
Start / End Page
741 / 749
Location
Greece
Related Subject Headings
- Regional Blood Flow
- Oxygen Consumption
- Oncology & Carcinogenesis
- Neoplasms
- Mitochondria
- Humans
- Glucose
- Energy Metabolism
- Cell Hypoxia
- Anemia