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dishevelled and armadillo act in the wingless signalling pathway in Drosophila.

Publication ,  Journal Article
Noordermeer, J; Klingensmith, J; Perrimon, N; Nusse, R
Published in: Nature
January 6, 1994

The Wnt genes encode conserved secreted proteins that play a role in normal development and tumorigenesis. Little is known about the signal transduction pathways of Wnt gene products. One of the best characterized Wnt family members is the Drosophila segment polarity gene wingless. We have investigated whether segment polarity genes with a wingless-like phenotype mediate the wingless signal. We used a wingless transgene controlled by a heat-shock promoter for genetic epistasis experiments. We show that wingless acts through dishevelled and armadillo to affect the expression of the homeobox gene engrailed and cuticle differentiation.

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Published In

Nature

DOI

ISSN

0028-0836

Publication Date

January 6, 1994

Volume

367

Issue

6458

Start / End Page

80 / 83

Location

England

Related Subject Headings

  • Wnt1 Protein
  • Transcription Factors
  • Trans-Activators
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Male
  • Insect Hormones
  • Homeodomain Proteins
 

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Noordermeer, J., Klingensmith, J., Perrimon, N., & Nusse, R. (1994). dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature, 367(6458), 80–83. https://doi.org/10.1038/367080a0
Noordermeer, J., J. Klingensmith, N. Perrimon, and R. Nusse. “dishevelled and armadillo act in the wingless signalling pathway in Drosophila.Nature 367, no. 6458 (January 6, 1994): 80–83. https://doi.org/10.1038/367080a0.
Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994 Jan 6;367(6458):80–3.
Noordermeer, J., et al. “dishevelled and armadillo act in the wingless signalling pathway in Drosophila.Nature, vol. 367, no. 6458, Jan. 1994, pp. 80–83. Pubmed, doi:10.1038/367080a0.
Noordermeer J, Klingensmith J, Perrimon N, Nusse R. dishevelled and armadillo act in the wingless signalling pathway in Drosophila. Nature. 1994 Jan 6;367(6458):80–83.
Journal cover image

Published In

Nature

DOI

ISSN

0028-0836

Publication Date

January 6, 1994

Volume

367

Issue

6458

Start / End Page

80 / 83

Location

England

Related Subject Headings

  • Wnt1 Protein
  • Transcription Factors
  • Trans-Activators
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Male
  • Insect Hormones
  • Homeodomain Proteins