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Signaling by wingless in Drosophila.

Publication ,  Journal Article
Klingensmith, J; Nusse, R
Published in: Dev Biol
December 1994

Wingless, a member of the Wnt gene family, is an essential gene for segmentation in Drosophila, and is also involved in many other patterning events. The gene encodes a secreted protein that can regulate gene expression in adjacent cells. Recently, significant progress has been made in elucidating the signal transduction pathway of wingless, mainly by genetic experiments but increasingly also at the biochemical level. While many components of wingless signaling, in particular a receptor, remain to be identified, our current understanding of wingless pathway is more advanced than that of other Wnt genes. We will give an overview of the various roles of wingless in development, and we will then summarize the wingless signaling pathway as it has emerged from genetic and biochemical studies. Where appropriate, wingless signaling will be compared to the activity of vertebrate Wnt proteins.

Duke Scholars

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Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

December 1994

Volume

166

Issue

2

Start / End Page

396 / 414

Location

United States

Related Subject Headings

  • alpha Catenin
  • Wnt1 Protein
  • Transcription Factors
  • Trans-Activators
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Morphogenesis
  • Genes, Insect
 

Citation

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Klingensmith, J., & Nusse, R. (1994). Signaling by wingless in Drosophila. Dev Biol, 166(2), 396–414. https://doi.org/10.1006/dbio.1994.1325
Klingensmith, J., and R. Nusse. “Signaling by wingless in Drosophila.Dev Biol 166, no. 2 (December 1994): 396–414. https://doi.org/10.1006/dbio.1994.1325.
Klingensmith J, Nusse R. Signaling by wingless in Drosophila. Dev Biol. 1994 Dec;166(2):396–414.
Klingensmith, J., and R. Nusse. “Signaling by wingless in Drosophila.Dev Biol, vol. 166, no. 2, Dec. 1994, pp. 396–414. Pubmed, doi:10.1006/dbio.1994.1325.
Klingensmith J, Nusse R. Signaling by wingless in Drosophila. Dev Biol. 1994 Dec;166(2):396–414.
Journal cover image

Published In

Dev Biol

DOI

ISSN

0012-1606

Publication Date

December 1994

Volume

166

Issue

2

Start / End Page

396 / 414

Location

United States

Related Subject Headings

  • alpha Catenin
  • Wnt1 Protein
  • Transcription Factors
  • Trans-Activators
  • Signal Transduction
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Morphogenesis
  • Genes, Insect