Skip to main content

The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.

Publication ,  Journal Article
Klingensmith, J; Nusse, R; Perrimon, N
Published in: Genes Dev
January 1994

The Drosophila Wnt-1 homolog, wingless (wg), is involved in the signaling of patterning information in several contexts. In the embryonic epidermis, Wg protein is secreted and taken up by neighboring cells, in which it is required for maintenance of engrailed transcription and accumulation of Armadillo protein. The dishevelled (dsh) gene mediates these signaling events as well as wg-dependent induction across tissue layers in the embryonic midgut. dsh is also required for the development processes in which wg functions in adult development. Overall, cells lacking dsh are unable to adopt fates specified by Wg. dsh functions cell autonomously, indicating that it is involved in the response of target cells to the Wg signal. dsh is expressed uniformly in the embryo and encodes a novel protein with no known catalytic motifs, although it shares a domain of homology with several junction-associated proteins. Our results demonstrate that dsh encodes a specific component of Wg signaling and illustrate that Wnt proteins may utilize a novel mechanism of extracellular signal transduction.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

January 1994

Volume

8

Issue

1

Start / End Page

118 / 130

Location

United States

Related Subject Headings

  • Wnt1 Protein
  • Transcription, Genetic
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Restriction Mapping
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Phenotype
  • Molecular Sequence Data
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Klingensmith, J., Nusse, R., & Perrimon, N. (1994). The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. Genes Dev, 8(1), 118–130. https://doi.org/10.1101/gad.8.1.118
Klingensmith, J., R. Nusse, and N. Perrimon. “The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Genes Dev 8, no. 1 (January 1994): 118–30. https://doi.org/10.1101/gad.8.1.118.
Klingensmith, J., et al. “The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal.Genes Dev, vol. 8, no. 1, Jan. 1994, pp. 118–30. Pubmed, doi:10.1101/gad.8.1.118.

Published In

Genes Dev

DOI

ISSN

0890-9369

Publication Date

January 1994

Volume

8

Issue

1

Start / End Page

118 / 130

Location

United States

Related Subject Headings

  • Wnt1 Protein
  • Transcription, Genetic
  • Signal Transduction
  • Sequence Homology, Amino Acid
  • Restriction Mapping
  • Proto-Oncogene Proteins
  • Proteins
  • Phosphoproteins
  • Phenotype
  • Molecular Sequence Data