Skip to main content
Journal cover image

Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.

Publication ,  Journal Article
Walters, MC; Patience, M; Leisenring, W; Rogers, ZR; Dinndorf, P; Davies, SC; Roberts, IA; Yeager, A; Kurtzberg, J; Bunin, N; Scott, JP ...
Published in: Biol Blood Marrow Transplant
December 1997

We present updated results of a multicenter collaborative investigation of bone marrow transplantation for sickle cell disease. Between September 1991 and April 1997, thirty-four children less than 16 years of age with severe sickle cell disease received marrow allografts from HLA-identical siblings. Indications for transplantation included a history of stroke (n = 17), recurrent acute chest syndrome or sickle pulmonary disease (n = 10), and recurrent vaso-occlusive crises (n = 7). Twenty-one patients received regular red blood cell (RBC) transfusions to prevent complications of sickle cell disease. Patients were prepared for transplantation with busulfan, cyclophosphamide, and antithymocyte globulin or CAMPATH (Cambridge Pathology) antibody. Thirty-two of the 34 patients survived, with a median follow-up of 26.5 months (range, 0.2-66.9 months); and 28 patients demonstrated stable engraftment of donor hematopoietic cells. Graft rejection or recurrence of sickle cell disease occurred in four patients, and two patients died of intracranial hemorrhage or graft-vs.-host disease. In the group of 34 children with symptoms of advanced sickle cell disease, current Kaplan-Meier estimates of survival and event-free survival are 93% and 79%, respectively.

Duke Scholars

Published In

Biol Blood Marrow Transplant

ISSN

1083-8791

Publication Date

December 1997

Volume

3

Issue

6

Start / End Page

310 / 315

Location

United States

Related Subject Headings

  • Transplantation Conditioning
  • Transplantation Chimera
  • Methotrexate
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Graft Rejection
  • Cyclosporine
  • Child, Preschool
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Walters, M. C., Patience, M., Leisenring, W., Rogers, Z. R., Dinndorf, P., Davies, S. C., … Sullivan, K. M. (1997). Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. Biol Blood Marrow Transplant, 3(6), 310–315.
Walters, M. C., M. Patience, W. Leisenring, Z. R. Rogers, P. Dinndorf, S. C. Davies, I. A. Roberts, et al. “Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.Biol Blood Marrow Transplant 3, no. 6 (December 1997): 310–15.
Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, et al. Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. Biol Blood Marrow Transplant. 1997 Dec;3(6):310–5.
Walters, M. C., et al. “Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.Biol Blood Marrow Transplant, vol. 3, no. 6, Dec. 1997, pp. 310–15.
Walters MC, Patience M, Leisenring W, Rogers ZR, Dinndorf P, Davies SC, Roberts IA, Yeager A, Kurtzberg J, Bunin N, Scott JP, Wall DA, Wayne AS, Wiley J, Darbyshire PJ, Mentzer WC, Smith FO, Sullivan KM. Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions. Biol Blood Marrow Transplant. 1997 Dec;3(6):310–315.
Journal cover image

Published In

Biol Blood Marrow Transplant

ISSN

1083-8791

Publication Date

December 1997

Volume

3

Issue

6

Start / End Page

310 / 315

Location

United States

Related Subject Headings

  • Transplantation Conditioning
  • Transplantation Chimera
  • Methotrexate
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Graft Rejection
  • Cyclosporine
  • Child, Preschool
  • Child