A solution to the cyclic aldol problem
Publication
, Journal Article
Baldwin, SW; Chen, P; Nikolic, N; Weinseimer, DC
Published in: Organic letters
May 2000
[formula: see text] A protocol for achieving stereoselective aldol reactions with cyclic ketones is presented. In terms of yield, the process is particularly effective when a quaternary center at the alpha-carbon of the beta-hydroxy ketone product is created. The stereochemical outcome, anti or syn, is achieved by the Lewis acid-mediated ring expansion of stereochemically homogeneous epoxides in a reaction related to the pinacol rearrangement.
Duke Scholars
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
May 2000
Volume
2
Issue
9
Start / End Page
1193 / 1196
Related Subject Headings
- Organic Chemistry
- 34 Chemical sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Baldwin, S. W., Chen, P., Nikolic, N., & Weinseimer, D. C. (2000). A solution to the cyclic aldol problem. Organic Letters, 2(9), 1193–1196. https://doi.org/10.1021/ol005525a
Baldwin, S. W., P. Chen, N. Nikolic, and D. C. Weinseimer. “A solution to the cyclic aldol problem.” Organic Letters 2, no. 9 (May 2000): 1193–96. https://doi.org/10.1021/ol005525a.
Baldwin SW, Chen P, Nikolic N, Weinseimer DC. A solution to the cyclic aldol problem. Organic letters. 2000 May;2(9):1193–6.
Baldwin, S. W., et al. “A solution to the cyclic aldol problem.” Organic Letters, vol. 2, no. 9, May 2000, pp. 1193–96. Epmc, doi:10.1021/ol005525a.
Baldwin SW, Chen P, Nikolic N, Weinseimer DC. A solution to the cyclic aldol problem. Organic letters. 2000 May;2(9):1193–1196.
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
May 2000
Volume
2
Issue
9
Start / End Page
1193 / 1196
Related Subject Headings
- Organic Chemistry
- 34 Chemical sciences
- 03 Chemical Sciences