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Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.

Publication ,  Journal Article
Kavanagh, BD; Halperin, EC; Rosenbaum, LC; Shannon, EM; Nilaver, G
Published in: Cancer
March 15, 1992

A patient with a primary undifferentiated carcinoma of the nasopharynx manifested the clinical syndrome of inappropriate antidiuretic hormone secretion (SIADH). Immunohistochemical techniques demonstrated the presence of vasopressin, neurophysin, and their precursor (propressophysin) in the cancer cells. In situ hybridization additionally confirmed the expression of propressophysin messenger RNA in these cells. To the knowledge of the authors, this represents not only the first case of SIADH caused by carcinoma of the nasopharynx, but also the first report of pathologic confirmation of the syndrome with the use of both molecular and immunologic probes.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1992

Volume

69

Issue

6

Start / End Page

1315 / 1319

Location

United States

Related Subject Headings

  • Vasopressins
  • Protein Precursors
  • Oxytocin
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Neurophysins
  • Nasopharyngeal Neoplasms
  • Middle Aged
  • Male
  • Inappropriate ADH Syndrome
 

Citation

APA
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MLA
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Kavanagh, B. D., Halperin, E. C., Rosenbaum, L. C., Shannon, E. M., & Nilaver, G. (1992). Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer, 69(6), 1315–1319. https://doi.org/10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2
Kavanagh, B. D., E. C. Halperin, L. C. Rosenbaum, E. M. Shannon, and G. Nilaver. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.Cancer 69, no. 6 (March 15, 1992): 1315–19. https://doi.org/10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2.
Kavanagh BD, Halperin EC, Rosenbaum LC, Shannon EM, Nilaver G. Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer. 1992 Mar 15;69(6):1315–9.
Kavanagh, B. D., et al. “Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.Cancer, vol. 69, no. 6, Mar. 1992, pp. 1315–19. Pubmed, doi:10.1002/1097-0142(19920315)69:6<1315::aid-cncr2820690602>3.0.co;2-2.
Kavanagh BD, Halperin EC, Rosenbaum LC, Shannon EM, Nilaver G. Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx. Cancer. 1992 Mar 15;69(6):1315–1319.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

March 15, 1992

Volume

69

Issue

6

Start / End Page

1315 / 1319

Location

United States

Related Subject Headings

  • Vasopressins
  • Protein Precursors
  • Oxytocin
  • Oncology & Carcinogenesis
  • Nucleic Acid Hybridization
  • Neurophysins
  • Nasopharyngeal Neoplasms
  • Middle Aged
  • Male
  • Inappropriate ADH Syndrome