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Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.

Publication ,  Journal Article
Graham, ML; Rosse, WF; Halperin, EC; Miller, CR; Ware, RE
Published in: Br J Haematol
March 1996

Thrombosis of the hepatic veins (Budd-Chiari syndrome) is a life-threatening thrombotic complication which can occur in patients with paroxysmal nocturnal haemoglobinuria (PNH). Despite aggressive medical and surgical therapy, mortality from Budd-Chiari syndrome remains high. We report a boy with PNH who developed Budd-Chiari syndrome and underwent syngeneic bone marrow transplantation (BMT). Now, 3 years following BMT, he has had dramatic clinical and radiographic evidence of resolution of the thrombosis. We suggest that BMT for PNH can successfully correct life-threatening thrombosis in patients with PNH.

Duke Scholars

Published In

Br J Haematol

DOI

ISSN

0007-1048

Publication Date

March 1996

Volume

92

Issue

3

Start / End Page

707 / 710

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Liver
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Child
  • Budd-Chiari Syndrome
  • Bone Marrow Transplantation
  • 3201 Cardiovascular medicine and haematology
 

Citation

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ICMJE
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Graham, M. L., Rosse, W. F., Halperin, E. C., Miller, C. R., & Ware, R. E. (1996). Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria. Br J Haematol, 92(3), 707–710. https://doi.org/10.1046/j.1365-2141.1996.365901.x
Graham, M. L., W. F. Rosse, E. C. Halperin, C. R. Miller, and R. E. Ware. “Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.Br J Haematol 92, no. 3 (March 1996): 707–10. https://doi.org/10.1046/j.1365-2141.1996.365901.x.
Graham ML, Rosse WF, Halperin EC, Miller CR, Ware RE. Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1996 Mar;92(3):707–10.
Graham, M. L., et al. “Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria.Br J Haematol, vol. 92, no. 3, Mar. 1996, pp. 707–10. Pubmed, doi:10.1046/j.1365-2141.1996.365901.x.
Graham ML, Rosse WF, Halperin EC, Miller CR, Ware RE. Resolution of Budd-Chiari syndrome following bone marrow transplantation for paroxysmal nocturnal haemoglobinuria. Br J Haematol. 1996 Mar;92(3):707–710.
Journal cover image

Published In

Br J Haematol

DOI

ISSN

0007-1048

Publication Date

March 1996

Volume

92

Issue

3

Start / End Page

707 / 710

Location

England

Related Subject Headings

  • Male
  • Magnetic Resonance Imaging
  • Liver
  • Immunology
  • Humans
  • Hemoglobinuria, Paroxysmal
  • Child
  • Budd-Chiari Syndrome
  • Bone Marrow Transplantation
  • 3201 Cardiovascular medicine and haematology