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Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes

Publication ,  Journal Article
Long, A; Baldwin, SW
Published in: Tetrahedron Letters
August 6, 2001

A new two-step route to derivatives of homophenylalanine is presented. Cycloaddition of a cyclic nitrone glycine template with various styrene derivatives affords good yields of 5-substituted cycloadducts. One-step hydrogenolysis (three bonds) then affords the optically pure α-amino acids related to homophenylalanine. © 2001 Published by Elsevier Science Ltd.

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Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

August 6, 2001

Volume

42

Issue

32

Start / End Page

5343 / 5345

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry
 

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Long, A., & Baldwin, S. W. (2001). Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes. Tetrahedron Letters, 42(32), 5343–5345. https://doi.org/10.1016/S0040-4039(01)00821-8
Long, A., and S. W. Baldwin. “Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes.” Tetrahedron Letters 42, no. 32 (August 6, 2001): 5343–45. https://doi.org/10.1016/S0040-4039(01)00821-8.
Long, A., and S. W. Baldwin. “Enantioselective syntheses of homophenylalanine derivatives via nitrone 1,3-dipolar cycloaddition reactions with styrenes.” Tetrahedron Letters, vol. 42, no. 32, Aug. 2001, pp. 5343–45. Scopus, doi:10.1016/S0040-4039(01)00821-8.
Journal cover image

Published In

Tetrahedron Letters

DOI

ISSN

0040-4039

Publication Date

August 6, 2001

Volume

42

Issue

32

Start / End Page

5343 / 5345

Related Subject Headings

  • Organic Chemistry
  • 3405 Organic chemistry
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0305 Organic Chemistry
  • 0304 Medicinal and Biomolecular Chemistry