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Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins.

Publication ,  Journal Article
Curry, WB; Grabe, MD; Kurnikov, IV; Skourtis, SS; Beratan, DN; Regan, JJ; Aquino, AJ; Beroza, P; Onuchic, JN
Published in: Journal of bioenergetics and biomembranes
June 1995

The simplest views of long-range electron transfer utilize flat one-dimensional barrier tunneling models, neglecting structural details of the protein medium. The pathway model of protein electron transfer reintroduces structure by distinguishing between covalent bonds, hydrogen bonds, and van der Waals contacts. These three kinds of interactions in a tunneling pathway each have distinctive decay factors associated with them. The distribution and arrangement of these bonded and nonbonded contacts in a folded protein varies tremendously between structures, adding a richness to the tunneling problem that is absent in simpler views. We review the pathway model and the predictions that it makes for protein electron transfer rates in small proteins, docked proteins, and the photosynthetic reactions center. We also review the formulation of the protein electron transfer problem as an effective two-level system. New multi-pathway approaches and improved electronic Hamiltonians are described briefly as well.

Duke Scholars

Published In

Journal of bioenergetics and biomembranes

DOI

EISSN

1573-6881

ISSN

0145-479X

Publication Date

June 1995

Volume

27

Issue

3

Start / End Page

285 / 293

Related Subject Headings

  • Proteins
  • Protein Structure, Secondary
  • Protein Conformation
  • Photosynthetic Reaction Center Complex Proteins
  • Models, Theoretical
  • Models, Molecular
  • Electron Transport
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Curry, W. B., Grabe, M. D., Kurnikov, I. V., Skourtis, S. S., Beratan, D. N., Regan, J. J., … Onuchic, J. N. (1995). Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. Journal of Bioenergetics and Biomembranes, 27(3), 285–293. https://doi.org/10.1007/bf02110098
Curry, W. B., M. D. Grabe, I. V. Kurnikov, S. S. Skourtis, D. N. Beratan, J. J. Regan, A. J. Aquino, P. Beroza, and J. N. Onuchic. “Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins.Journal of Bioenergetics and Biomembranes 27, no. 3 (June 1995): 285–93. https://doi.org/10.1007/bf02110098.
Curry WB, Grabe MD, Kurnikov IV, Skourtis SS, Beratan DN, Regan JJ, et al. Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. Journal of bioenergetics and biomembranes. 1995 Jun;27(3):285–93.
Curry, W. B., et al. “Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins.Journal of Bioenergetics and Biomembranes, vol. 27, no. 3, June 1995, pp. 285–93. Epmc, doi:10.1007/bf02110098.
Curry WB, Grabe MD, Kurnikov IV, Skourtis SS, Beratan DN, Regan JJ, Aquino AJ, Beroza P, Onuchic JN. Pathways, pathway tubes, pathway docking, and propagators in electron transfer proteins. Journal of bioenergetics and biomembranes. 1995 Jun;27(3):285–293.
Journal cover image

Published In

Journal of bioenergetics and biomembranes

DOI

EISSN

1573-6881

ISSN

0145-479X

Publication Date

June 1995

Volume

27

Issue

3

Start / End Page

285 / 293

Related Subject Headings

  • Proteins
  • Protein Structure, Secondary
  • Protein Conformation
  • Photosynthetic Reaction Center Complex Proteins
  • Models, Theoretical
  • Models, Molecular
  • Electron Transport
  • Biochemistry & Molecular Biology
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology