Skip to main content
Journal cover image

Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.

Publication ,  Journal Article
Li, P; Dobrikov, M; Liu, H; Shaw, BR
Published in: Organic letters
July 2003

[reaction: see text] The first example of an acyclonucleoside alpha-P-boranotriphosphate has been synthesized via a phosphoramidite approach in a one-pot reaction with good yield. The presence of the alpha-P-BH(3) in 5b results in a 9-fold increase in efficiency of incorporation by MMLV retroviral reverse transcriptase relative to non-boronated 5a in pre-steady-state conditions. The preliminary results indicate that acyclonucleoside alpha-P-boranotriphosphates may have promising applications as a probe of enzyme mechanisms and in the design of new antiviral drugs.

Duke Scholars

Published In

Organic letters

DOI

EISSN

1523-7052

ISSN

1523-7060

Publication Date

July 2003

Volume

5

Issue

14

Start / End Page

2401 / 2403

Related Subject Headings

  • Uracil
  • Substrate Specificity
  • RNA-Directed DNA Polymerase
  • Organic Chemistry
  • Leukemia Virus, Murine
  • Boron Compounds
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, P., Dobrikov, M., Liu, H., & Shaw, B. R. (2003). Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. Organic Letters, 5(14), 2401–2403. https://doi.org/10.1021/ol034538w
Li, Ping, Mikhail Dobrikov, Hongyan Liu, and Barbara Ramsay Shaw. “Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.Organic Letters 5, no. 14 (July 2003): 2401–3. https://doi.org/10.1021/ol034538w.
Li, Ping, et al. “Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.Organic Letters, vol. 5, no. 14, July 2003, pp. 2401–03. Epmc, doi:10.1021/ol034538w.
Journal cover image

Published In

Organic letters

DOI

EISSN

1523-7052

ISSN

1523-7060

Publication Date

July 2003

Volume

5

Issue

14

Start / End Page

2401 / 2403

Related Subject Headings

  • Uracil
  • Substrate Specificity
  • RNA-Directed DNA Polymerase
  • Organic Chemistry
  • Leukemia Virus, Murine
  • Boron Compounds
  • 34 Chemical sciences
  • 03 Chemical Sciences