Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.
Publication
, Journal Article
Li, P; Dobrikov, M; Liu, H; Shaw, BR
Published in: Organic letters
July 2003
[reaction: see text] The first example of an acyclonucleoside alpha-P-boranotriphosphate has been synthesized via a phosphoramidite approach in a one-pot reaction with good yield. The presence of the alpha-P-BH(3) in 5b results in a 9-fold increase in efficiency of incorporation by MMLV retroviral reverse transcriptase relative to non-boronated 5a in pre-steady-state conditions. The preliminary results indicate that acyclonucleoside alpha-P-boranotriphosphates may have promising applications as a probe of enzyme mechanisms and in the design of new antiviral drugs.
Duke Scholars
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
July 2003
Volume
5
Issue
14
Start / End Page
2401 / 2403
Related Subject Headings
- Uracil
- Substrate Specificity
- RNA-Directed DNA Polymerase
- Organic Chemistry
- Leukemia Virus, Murine
- Boron Compounds
- 34 Chemical sciences
- 03 Chemical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, P., Dobrikov, M., Liu, H., & Shaw, B. R. (2003). Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. Organic Letters, 5(14), 2401–2403. https://doi.org/10.1021/ol034538w
Li, Ping, Mikhail Dobrikov, Hongyan Liu, and Barbara Ramsay Shaw. “Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.” Organic Letters 5, no. 14 (July 2003): 2401–3. https://doi.org/10.1021/ol034538w.
Li P, Dobrikov M, Liu H, Shaw BR. Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. Organic letters. 2003 Jul;5(14):2401–3.
Li, Ping, et al. “Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase.” Organic Letters, vol. 5, no. 14, July 2003, pp. 2401–03. Epmc, doi:10.1021/ol034538w.
Li P, Dobrikov M, Liu H, Shaw BR. Synthesis of acyclothymidine triphosphate and alpha-P-boranotriphosphate and their substrate properties with retroviral reverse transcriptase. Organic letters. 2003 Jul;5(14):2401–2403.
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
July 2003
Volume
5
Issue
14
Start / End Page
2401 / 2403
Related Subject Headings
- Uracil
- Substrate Specificity
- RNA-Directed DNA Polymerase
- Organic Chemistry
- Leukemia Virus, Murine
- Boron Compounds
- 34 Chemical sciences
- 03 Chemical Sciences