RNase H activation by stereoregular boranophosphate oligonucleotide.
Publication
, Journal Article
Wang, X; Dobrikov, M; Sergueev, D; Shaw, BR
Published in: Nucleosides, nucleotides & nucleic acids
May 2003
A stereoregular all-(Sp)-boranophosphate oligodeoxyribonucleotide (BH3(-)-ODN) 15-mer was synthesized using an enzymatic approach. The BH3(-)-ODN formed a hybrid with the complementary RNA 15-mer and induced RNase H hydrolysis of the RNA strand at ODN concentrations as low as 10 nM at 37 degrees C, but with a lower efficiency than that of its natural phosphodiester analogue.
Duke Scholars
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
May 2003
Volume
22
Issue
5-8
Start / End Page
1151 / 1153
Related Subject Headings
- Substrate Specificity
- Ribonuclease H
- Organic Chemistry
- Oligonucleotides
- Oligodeoxyribonucleotides
- Nucleic Acid Conformation
- Kinetics
- Genes, erbB-2
- Enzyme Activation
- Boron Compounds
Citation
APA
Chicago
ICMJE
MLA
NLM
Wang, X., Dobrikov, M., Sergueev, D., & Shaw, B. R. (2003). RNase H activation by stereoregular boranophosphate oligonucleotide. Nucleosides, Nucleotides & Nucleic Acids, 22(5–8), 1151–1153. https://doi.org/10.1081/ncn-120022823
Wang, Xin, Mikhail Dobrikov, Dmitri Sergueev, and Barbara Ramsay Shaw. “RNase H activation by stereoregular boranophosphate oligonucleotide.” Nucleosides, Nucleotides & Nucleic Acids 22, no. 5–8 (May 2003): 1151–53. https://doi.org/10.1081/ncn-120022823.
Wang X, Dobrikov M, Sergueev D, Shaw BR. RNase H activation by stereoregular boranophosphate oligonucleotide. Nucleosides, nucleotides & nucleic acids. 2003 May;22(5–8):1151–3.
Wang, Xin, et al. “RNase H activation by stereoregular boranophosphate oligonucleotide.” Nucleosides, Nucleotides & Nucleic Acids, vol. 22, no. 5–8, May 2003, pp. 1151–53. Epmc, doi:10.1081/ncn-120022823.
Wang X, Dobrikov M, Sergueev D, Shaw BR. RNase H activation by stereoregular boranophosphate oligonucleotide. Nucleosides, nucleotides & nucleic acids. 2003 May;22(5–8):1151–1153.
Published In
Nucleosides, nucleotides & nucleic acids
DOI
EISSN
1532-2335
ISSN
1525-7770
Publication Date
May 2003
Volume
22
Issue
5-8
Start / End Page
1151 / 1153
Related Subject Headings
- Substrate Specificity
- Ribonuclease H
- Organic Chemistry
- Oligonucleotides
- Oligodeoxyribonucleotides
- Nucleic Acid Conformation
- Kinetics
- Genes, erbB-2
- Enzyme Activation
- Boron Compounds