Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate
Publication
, Journal Article
Lin, J; Shaw, BR
Published in: Chemical Communications
August 21, 1999
The first boranophosphorothioate [(RO)2P(S)(BH3)-] mimic of a phosphodiester compound, dithymidine boranophosphorothioate, has been synthesized; while it is water soluble, this new analogue is more lipophilic and nuclease resistant than natural nucleoside phosphodiesters [(RO)2P(O)(O)-] and phosphorothioates [(RO)2P(S)(O)-].
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Published In
Chemical Communications
DOI
ISSN
1359-7345
Publication Date
August 21, 1999
Issue
16
Start / End Page
1517 / 1518
Related Subject Headings
- Organic Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences
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Lin, J., & Shaw, B. R. (1999). Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate. Chemical Communications, (16), 1517–1518. https://doi.org/10.1039/a901157i
Lin, J., and B. R. Shaw. “Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate.” Chemical Communications, no. 16 (August 21, 1999): 1517–18. https://doi.org/10.1039/a901157i.
Lin J, Shaw BR. Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate. Chemical Communications. 1999 Aug 21;(16):1517–8.
Lin, J., and B. R. Shaw. “Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate.” Chemical Communications, no. 16, Aug. 1999, pp. 1517–18. Scopus, doi:10.1039/a901157i.
Lin J, Shaw BR. Synthesis and properties of a novel phosphodiester analogue, nucleoside boranophosphorothioate. Chemical Communications. 1999 Aug 21;(16):1517–1518.
Published In
Chemical Communications
DOI
ISSN
1359-7345
Publication Date
August 21, 1999
Issue
16
Start / End Page
1517 / 1518
Related Subject Headings
- Organic Chemistry
- 40 Engineering
- 34 Chemical sciences
- 03 Chemical Sciences