Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.
Publication
, Journal Article
Li, P; Shaw, BR
Published in: Organic letters
June 2002
[structure: see text] Preparation of antiviral and anticancer prodrug candidates, P-tyrosinyl(P-O)-5'-P-nucleosidyl boranophosphates, is described. One-pot synthesis via a phosphoramidite method resulted in the title compounds with good yields. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by 1H and 31P NMR spectroscopy and MS analysis.
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Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
June 2002
Volume
4
Issue
12
Start / End Page
2009 / 2012
Related Subject Headings
- Stereoisomerism
- Prodrugs
- Phosphates
- Organic Chemistry
- Nucleosides
- Molecular Structure
- Mass Spectrometry
- Magnetic Resonance Spectroscopy
- Chromatography, High Pressure Liquid
- Antiviral Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Li, P., & Shaw, B. R. (2002). Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. Organic Letters, 4(12), 2009–2012. https://doi.org/10.1021/ol025832b
Li, Ping, and Barbara Ramsay Shaw. “Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.” Organic Letters 4, no. 12 (June 2002): 2009–12. https://doi.org/10.1021/ol025832b.
Li P, Shaw BR. Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. Organic letters. 2002 Jun;4(12):2009–12.
Li, Ping, and Barbara Ramsay Shaw. “Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate.” Organic Letters, vol. 4, no. 12, June 2002, pp. 2009–12. Epmc, doi:10.1021/ol025832b.
Li P, Shaw BR. Synthesis of prodrug candidates: conjugates of amino acid with nucleoside boranophosphate. Organic letters. 2002 Jun;4(12):2009–2012.
Published In
Organic letters
DOI
EISSN
1523-7052
ISSN
1523-7060
Publication Date
June 2002
Volume
4
Issue
12
Start / End Page
2009 / 2012
Related Subject Headings
- Stereoisomerism
- Prodrugs
- Phosphates
- Organic Chemistry
- Nucleosides
- Molecular Structure
- Mass Spectrometry
- Magnetic Resonance Spectroscopy
- Chromatography, High Pressure Liquid
- Antiviral Agents