Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.
Publication
, Journal Article
Hall, IH; Das, MK; Harchelroad, F; Wisian-Neilson, P; McPhail, AT; Spielvogel, BF
Published in: Journal of pharmaceutical sciences
March 1981
A series of amine cyanoboranes and amine carboxyboranes were observed to be antihyperlipidemic agents in mice; i.e., they lowered serum cholesterol and triglyceride levels significantly. These compounds appeared to inhibit lipid synthesis in the early stages. The ability to lower serum cholesterol levels appeared to correlate with the suppression of the regulatory enzyme of cholesterol synthesis, beta-hydroxy-beta-methylglutaryl-CoA reductase activity. The reduction of serum triglycerides correlated with ability of the borane compound to suppress liver fatty acid synthetase activity.
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Published In
Journal of pharmaceutical sciences
DOI
EISSN
1520-6017
ISSN
0022-3549
Publication Date
March 1981
Volume
70
Issue
3
Start / End Page
339 / 341
Related Subject Headings
- Pharmacology & Pharmacy
- Mice
- Male
- Hypolipidemic Agents
- Fatty Acids
- Cholesterol
- Boranes
- Animals
- Amino Acids
- Acetate-CoA Ligase
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MLA
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Hall, I. H., Das, M. K., Harchelroad, F., Wisian-Neilson, P., McPhail, A. T., & Spielvogel, B. F. (1981). Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of Pharmaceutical Sciences, 70(3), 339–341. https://doi.org/10.1002/jps.2600700333
Hall, I. H., M. K. Das, F. Harchelroad, P. Wisian-Neilson, A. T. McPhail, and B. F. Spielvogel. “Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.” Journal of Pharmaceutical Sciences 70, no. 3 (March 1981): 339–41. https://doi.org/10.1002/jps.2600700333.
Hall IH, Das MK, Harchelroad F, Wisian-Neilson P, McPhail AT, Spielvogel BF. Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of pharmaceutical sciences. 1981 Mar;70(3):339–41.
Hall, I. H., et al. “Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.” Journal of Pharmaceutical Sciences, vol. 70, no. 3, Mar. 1981, pp. 339–41. Epmc, doi:10.1002/jps.2600700333.
Hall IH, Das MK, Harchelroad F, Wisian-Neilson P, McPhail AT, Spielvogel BF. Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of pharmaceutical sciences. 1981 Mar;70(3):339–341.
Published In
Journal of pharmaceutical sciences
DOI
EISSN
1520-6017
ISSN
0022-3549
Publication Date
March 1981
Volume
70
Issue
3
Start / End Page
339 / 341
Related Subject Headings
- Pharmacology & Pharmacy
- Mice
- Male
- Hypolipidemic Agents
- Fatty Acids
- Cholesterol
- Boranes
- Animals
- Amino Acids
- Acetate-CoA Ligase