Skip to main content
Journal cover image

Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.

Publication ,  Journal Article
Hall, IH; Das, MK; Harchelroad, F; Wisian-Neilson, P; McPhail, AT; Spielvogel, BF
Published in: Journal of pharmaceutical sciences
March 1981

A series of amine cyanoboranes and amine carboxyboranes were observed to be antihyperlipidemic agents in mice; i.e., they lowered serum cholesterol and triglyceride levels significantly. These compounds appeared to inhibit lipid synthesis in the early stages. The ability to lower serum cholesterol levels appeared to correlate with the suppression of the regulatory enzyme of cholesterol synthesis, beta-hydroxy-beta-methylglutaryl-CoA reductase activity. The reduction of serum triglycerides correlated with ability of the borane compound to suppress liver fatty acid synthetase activity.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Journal of pharmaceutical sciences

DOI

EISSN

1520-6017

ISSN

0022-3549

Publication Date

March 1981

Volume

70

Issue

3

Start / End Page

339 / 341

Related Subject Headings

  • Pharmacology & Pharmacy
  • Mice
  • Male
  • Hypolipidemic Agents
  • Fatty Acids
  • Cholesterol
  • Boranes
  • Animals
  • Amino Acids
  • Acetate-CoA Ligase
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hall, I. H., Das, M. K., Harchelroad, F., Wisian-Neilson, P., McPhail, A. T., & Spielvogel, B. F. (1981). Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of Pharmaceutical Sciences, 70(3), 339–341. https://doi.org/10.1002/jps.2600700333
Hall, I. H., M. K. Das, F. Harchelroad, P. Wisian-Neilson, A. T. McPhail, and B. F. Spielvogel. “Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.Journal of Pharmaceutical Sciences 70, no. 3 (March 1981): 339–41. https://doi.org/10.1002/jps.2600700333.
Hall IH, Das MK, Harchelroad F, Wisian-Neilson P, McPhail AT, Spielvogel BF. Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of pharmaceutical sciences. 1981 Mar;70(3):339–41.
Hall, I. H., et al. “Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds.Journal of Pharmaceutical Sciences, vol. 70, no. 3, Mar. 1981, pp. 339–41. Epmc, doi:10.1002/jps.2600700333.
Hall IH, Das MK, Harchelroad F, Wisian-Neilson P, McPhail AT, Spielvogel BF. Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. Journal of pharmaceutical sciences. 1981 Mar;70(3):339–341.
Journal cover image

Published In

Journal of pharmaceutical sciences

DOI

EISSN

1520-6017

ISSN

0022-3549

Publication Date

March 1981

Volume

70

Issue

3

Start / End Page

339 / 341

Related Subject Headings

  • Pharmacology & Pharmacy
  • Mice
  • Male
  • Hypolipidemic Agents
  • Fatty Acids
  • Cholesterol
  • Boranes
  • Animals
  • Amino Acids
  • Acetate-CoA Ligase