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Differential adaptation of the linear and nonlinear components of the horizontal vestibuloocular reflex in squirrel monkeys.

Publication ,  Journal Article
Clendaniel, RA; Lasker, DM; Minor, LB
Published in: J Neurophysiol
December 2002

Previous work in squirrel monkeys has demonstrated the presence of linear and nonlinear components to the horizontal vestibuloocular reflex (VOR) evoked by high-acceleration rotations. The nonlinear component is seen as a rise in gain with increasing velocity of rotation at frequencies more than 2 Hz (a velocity-dependent gain enhancement). We have shown that there are greater changes in the nonlinear than linear component of the response after spectacle-induced adaptation. The present study was conducted to determine if the two components of the response share a common adaptive process. The gain of the VOR, in the dark, to sinusoidal stimuli at 4 Hz (peak velocities: 20-150 degrees /s) and 10 Hz (peak velocities: 20 and 100 degrees /s) was measured pre- and postadaptation. Adaptation was induced over 4 h with x0.45 minimizing spectacles. Sum-of-sines stimuli were used to induce adaptation, and the parameters of the stimuli were adjusted to invoke only the linear or both linear and nonlinear components of the response. Preadaptation, there was a velocity-dependent gain enhancement at 4 and 10 Hz. In postadaptation with the paradigms that only recruited the linear component, there was a decrease in gain and a persistent velocity-dependent gain enhancement (indicating adaptation of only the linear component). After adaptation with the paradigm designed to recruit both the linear and nonlinear components, there was a decrease in gain and no velocity-dependent gain enhancement (indicating adaptation of both components). There were comparable changes in the response to steps of acceleration. We interpret these results to indicate that separate processes drive the adaptation of the linear and nonlinear components of the response.

Duke Scholars

Published In

J Neurophysiol

DOI

ISSN

0022-3077

Publication Date

December 2002

Volume

88

Issue

6

Start / End Page

3534 / 3540

Location

United States

Related Subject Headings

  • Saimiri
  • Rotation
  • Reflex, Vestibulo-Ocular
  • Nonlinear Dynamics
  • Neurology & Neurosurgery
  • Models, Biological
  • Linear Models
  • Animals
  • Adaptation, Physiological
  • Acceleration
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clendaniel, R. A., Lasker, D. M., & Minor, L. B. (2002). Differential adaptation of the linear and nonlinear components of the horizontal vestibuloocular reflex in squirrel monkeys. J Neurophysiol, 88(6), 3534–3540. https://doi.org/10.1152/jn.00404.2002
Clendaniel, Richard A., David M. Lasker, and Lloyd B. Minor. “Differential adaptation of the linear and nonlinear components of the horizontal vestibuloocular reflex in squirrel monkeys.J Neurophysiol 88, no. 6 (December 2002): 3534–40. https://doi.org/10.1152/jn.00404.2002.
Clendaniel, Richard A., et al. “Differential adaptation of the linear and nonlinear components of the horizontal vestibuloocular reflex in squirrel monkeys.J Neurophysiol, vol. 88, no. 6, Dec. 2002, pp. 3534–40. Pubmed, doi:10.1152/jn.00404.2002.

Published In

J Neurophysiol

DOI

ISSN

0022-3077

Publication Date

December 2002

Volume

88

Issue

6

Start / End Page

3534 / 3540

Location

United States

Related Subject Headings

  • Saimiri
  • Rotation
  • Reflex, Vestibulo-Ocular
  • Nonlinear Dynamics
  • Neurology & Neurosurgery
  • Models, Biological
  • Linear Models
  • Animals
  • Adaptation, Physiological
  • Acceleration