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Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. IV. Responses after spectacle-induced adaptation.

Publication ,  Journal Article
Clendaniel, RA; Lasker, DM; Minor, LB
Published in: J Neurophysiol
October 2001

The horizontal angular vestibuloocular reflex (VOR) evoked by sinusoidal rotations from 0.5 to 15 Hz and acceleration steps up to 3,000 degrees /s(2) to 150 degrees /s was studied in six squirrel monkeys following adaptation with x2.2 magnifying and x0.45 minimizing spectacles. For sinusoidal rotations with peak velocities of 20 degrees /s, there were significant changes in gain at all frequencies; however, the greatest gain changes occurred at the lower frequencies. The frequency- and velocity-dependent gain enhancement seen in normal monkeys was accentuated following adaptation to magnifying spectacles and diminished with adaptation to minimizing spectacles. A differential increase in gain for the steps of acceleration was noted after adaptation to the magnifying spectacles. The gain during the acceleration portion, G(A), of a step of acceleration (3,000 degrees /s(2) to 150 degrees /s) increased from preadaptation values of 1.05 +/- 0.08 to 1.96 +/- 0.16, while the gain during the velocity plateau, G(V), only increased from 0.93 +/- 0.04 to 1.36 +/- 0.08. Polynomial fits to the trajectory of the response during the acceleration step revealed a greater increase in the cubic than the linear term following adaptation with the magnifying lenses. Following adaptation to the minimizing lenses, the value of G(A) decreased to 0.61 +/- 0.08, and the value of G(V) decreased to 0.59 +/- 0.09 for the 3,000 degrees /s(2) steps of acceleration. Polynomial fits to the trajectory of the response during the acceleration step revealed that there was a significantly greater reduction in the cubic term than in the linear term following adaptation with the minimizing lenses. These findings indicate that there is greater modification of the nonlinear as compared with the linear component of the VOR with spectacle-induced adaptation. In addition, the latency to the onset of the adapted response varied with the dynamics of the stimulus. The findings were modeled with a bilateral model of the VOR containing linear and nonlinear pathways that describe the normal behavior and adaptive processes. Adaptation for the linear pathway is described by a transfer function that shows the dependence of adaptation on the frequency of the head movement. The adaptive process for the nonlinear pathway is a gain enhancement element that provides for the accentuated gain with rising head velocity and the increased cubic component of the responses to steps of acceleration. While this model is substantially different from earlier models of VOR adaptation, it accounts for the data in the present experiments and also predicts the findings observed in the earlier studies.

Duke Scholars

Published In

J Neurophysiol

DOI

ISSN

0022-3077

Publication Date

October 2001

Volume

86

Issue

4

Start / End Page

1594 / 1611

Location

United States

Related Subject Headings

  • Saimiri
  • Rotation
  • Reflex, Vestibulo-Ocular
  • Reaction Time
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Neural Pathways
  • Eyeglasses
  • Eye Movements
  • Deceleration
 

Citation

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Clendaniel, R. A., Lasker, D. M., & Minor, L. B. (2001). Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. IV. Responses after spectacle-induced adaptation. J Neurophysiol, 86(4), 1594–1611. https://doi.org/10.1152/jn.2001.86.4.1594
Clendaniel, R. A., D. M. Lasker, and L. B. Minor. “Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. IV. Responses after spectacle-induced adaptation.J Neurophysiol 86, no. 4 (October 2001): 1594–1611. https://doi.org/10.1152/jn.2001.86.4.1594.
Clendaniel, R. A., et al. “Horizontal vestibuloocular reflex evoked by high-acceleration rotations in the squirrel monkey. IV. Responses after spectacle-induced adaptation.J Neurophysiol, vol. 86, no. 4, Oct. 2001, pp. 1594–611. Pubmed, doi:10.1152/jn.2001.86.4.1594.

Published In

J Neurophysiol

DOI

ISSN

0022-3077

Publication Date

October 2001

Volume

86

Issue

4

Start / End Page

1594 / 1611

Location

United States

Related Subject Headings

  • Saimiri
  • Rotation
  • Reflex, Vestibulo-Ocular
  • Reaction Time
  • Photic Stimulation
  • Neurology & Neurosurgery
  • Neural Pathways
  • Eyeglasses
  • Eye Movements
  • Deceleration