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Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex.

Publication ,  Journal Article
Bosking, WH; Zhang, Y; Schofield, B; Fitzpatrick, D
Published in: J Neurosci
March 15, 1997

Horizontal connections, formed primarily by the axon collaterals of pyramidal neurons in layer 2/3 of visual cortex, extend for millimeters parallel to the cortical surface and form patchy terminations. Previous studies have provided evidence that the patches formed by horizontal connections exhibit modular specificity, preferentially linking columns of neurons with similar response characteristics, such as preferred orientation. The issue of how these connections are distributed with respect to the topographic map of visual space, however, has not been resolved. Here we combine optical imaging of intrinsic signals with small extracellular injections of biocytin to assess quantitatively the specificity of horizontal connections with respect to both the map of orientation preference and the map of visual space in tree shrew V1. Our results indicate that horizontal connections outside a radius of 500 microm from the injection site exhibit not only modular specificity, but also specificity for axis of projection. Labeled axons extend for longer distances, and give off more terminal boutons, along an axis in the map of visual space that corresponds to the preferred orientation of the injection site. Inside of 500 microm, the pattern of connections is much less specific, with boutons found along every axis, contacting sites with a wide range of preferred orientations. The system of long-range horizontal connections can be summarized as preferentially linking neurons with co-oriented, co-axially aligned receptive fields. These observations suggest specific ways that horizontal circuits contribute to the response properties of layer 2/3 neurons and to mechanisms of visual perception.

Duke Scholars

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Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

March 15, 1997

Volume

17

Issue

6

Start / End Page

2112 / 2127

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Shrews
  • Neurology & Neurosurgery
  • Corpus Striatum
  • Animals
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Bosking, W. H., Zhang, Y., Schofield, B., & Fitzpatrick, D. (1997). Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci, 17(6), 2112–2127. https://doi.org/10.1523/JNEUROSCI.17-06-02112.1997
Bosking, W. H., Y. Zhang, B. Schofield, and D. Fitzpatrick. “Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex.J Neurosci 17, no. 6 (March 15, 1997): 2112–27. https://doi.org/10.1523/JNEUROSCI.17-06-02112.1997.
Bosking WH, Zhang Y, Schofield B, Fitzpatrick D. Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci. 1997 Mar 15;17(6):2112–27.
Bosking, W. H., et al. “Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex.J Neurosci, vol. 17, no. 6, Mar. 1997, pp. 2112–27. Pubmed, doi:10.1523/JNEUROSCI.17-06-02112.1997.
Bosking WH, Zhang Y, Schofield B, Fitzpatrick D. Orientation selectivity and the arrangement of horizontal connections in tree shrew striate cortex. J Neurosci. 1997 Mar 15;17(6):2112–2127.

Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

March 15, 1997

Volume

17

Issue

6

Start / End Page

2112 / 2127

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Shrews
  • Neurology & Neurosurgery
  • Corpus Striatum
  • Animals
  • 3209 Neurosciences
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences