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Laminar asymmetry in the distribution of choline acetyltransferase-immunoreactive neurons in the retina of the tree shrew (Tupaia belangeri).

Publication ,  Journal Article
Conley, M; Fitzpatrick, D; Lachica, EA
Published in: Brain Res
December 10, 1986

Cholinergic neurons in the retina of the tree shrew were identified immunocytochemically using a monoclonal antibody directed against choline acetyltransferase (ChAT). The chief result is that roughly 4 times as many ChAT-immunoreactive neurons are found in the inner nuclear layer (INL) as in the ganglion cell layer (GCL). In the INL, two classes of cholinergic neuron can be distinguished on the basis of soma size, one large and one small. The large neurons correspond closely in size and number to the displaced cholinergic neurons in the GCL, suggesting that these are the matching populations of cholinergic amacrine cells reported in other species. The small ChAT-immunoreactive neurons, on the other hand, which make up 60% of the total number of ChAT-positive neurons in the retina, appear to have no counterpart in the GCL. Whether these small neurons are a separate class of amacrine cell or some other cell type (e.g. bipolar, interplexiform, etc.) remains to be determined.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 10, 1986

Volume

399

Issue

2

Start / End Page

332 / 338

Location

Netherlands

Related Subject Headings

  • Tupaiidae
  • Retinal Ganglion Cells
  • Retina
  • Neurons
  • Neurology & Neurosurgery
  • Immunologic Techniques
  • Choline O-Acetyltransferase
  • Cell Count
  • Antibodies, Monoclonal
  • Animals
 

Citation

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Conley, M., Fitzpatrick, D., & Lachica, E. A. (1986). Laminar asymmetry in the distribution of choline acetyltransferase-immunoreactive neurons in the retina of the tree shrew (Tupaia belangeri). Brain Res, 399(2), 332–338. https://doi.org/10.1016/0006-8993(86)91524-6
Conley, M., D. Fitzpatrick, and E. A. Lachica. “Laminar asymmetry in the distribution of choline acetyltransferase-immunoreactive neurons in the retina of the tree shrew (Tupaia belangeri).Brain Res 399, no. 2 (December 10, 1986): 332–38. https://doi.org/10.1016/0006-8993(86)91524-6.
Conley, M., et al. “Laminar asymmetry in the distribution of choline acetyltransferase-immunoreactive neurons in the retina of the tree shrew (Tupaia belangeri).Brain Res, vol. 399, no. 2, Dec. 1986, pp. 332–38. Pubmed, doi:10.1016/0006-8993(86)91524-6.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

December 10, 1986

Volume

399

Issue

2

Start / End Page

332 / 338

Location

Netherlands

Related Subject Headings

  • Tupaiidae
  • Retinal Ganglion Cells
  • Retina
  • Neurons
  • Neurology & Neurosurgery
  • Immunologic Techniques
  • Choline O-Acetyltransferase
  • Cell Count
  • Antibodies, Monoclonal
  • Animals