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The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex.

Publication ,  Journal Article
Muly, EC; Fitzpatrick, D
Published in: J Neurosci
April 1992

We used retrograde and anterograde transport methods and single-cell reconstructions to examine the projection from layer IV to supragranular layers in the tree shrew's striate cortex. We found that neurons in the ON and OFF subdivisions of layer IV (IVa and IVb, respectively) have overlapping terminal fields throughout layers II and III. Despite their overlap, these projections are organized in a highly stratified, mirror-symmetric fashion that respects the vertical position of neurons within each sublayer. Neurons in the middle of layer IV (lower IVa and upper IVb) project to layers IIIa/b, II, and I; neurons located at the edges of layer IV (upper IVa and lower IVb) project to the lower half of layer IIIc; and neurons in the middle of IVa and the middle of IVb project to upper IIIc. The stratified nature of the projections from layer IV to layer III is reminiscent of the pattern of ipsilateral and contralateral eye inputs to layer IV. Inputs from the ipsilateral eye are limited to the edges of layer IV (upper IVa and lower IVb), while those from the contralateral eye terminate throughout the depth of IVa and IVb. Thus, cells near the edges of layer IV should receive strong input from both eyes, while those in the middle of layer IV should receive mostly contralateral input. Taken together, these results suggest that the projections from layer IV to layer III bring together the information conveyed by the ON and OFF pathways, but do so in a way that matches the ocular dominance characteristics for each pathway.

Duke Scholars

Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

April 1992

Volume

12

Issue

4

Start / End Page

1319 / 1334

Location

United States

Related Subject Headings

  • Visual Cortex
  • Vision, Binocular
  • Tupaiidae
  • Synaptic Transmission
  • Neurons
  • Neurology & Neurosurgery
  • Male
  • Horseradish Peroxidase
  • Female
  • Convergence, Ocular
 

Citation

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Muly, E. C., & Fitzpatrick, D. (1992). The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex. J Neurosci, 12(4), 1319–1334. https://doi.org/10.1523/JNEUROSCI.12-04-01319.1992
Muly, E. C., and D. Fitzpatrick. “The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex.J Neurosci 12, no. 4 (April 1992): 1319–34. https://doi.org/10.1523/JNEUROSCI.12-04-01319.1992.
Muly EC, Fitzpatrick D. The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex. J Neurosci. 1992 Apr;12(4):1319–34.
Muly, E. C., and D. Fitzpatrick. “The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex.J Neurosci, vol. 12, no. 4, Apr. 1992, pp. 1319–34. Pubmed, doi:10.1523/JNEUROSCI.12-04-01319.1992.
Muly EC, Fitzpatrick D. The morphological basis for binocular and ON/OFF convergence in tree shrew striate cortex. J Neurosci. 1992 Apr;12(4):1319–1334.

Published In

J Neurosci

DOI

ISSN

0270-6474

Publication Date

April 1992

Volume

12

Issue

4

Start / End Page

1319 / 1334

Location

United States

Related Subject Headings

  • Visual Cortex
  • Vision, Binocular
  • Tupaiidae
  • Synaptic Transmission
  • Neurons
  • Neurology & Neurosurgery
  • Male
  • Horseradish Peroxidase
  • Female
  • Convergence, Ocular