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A morphological basis for orientation tuning in primary visual cortex.

Publication ,  Journal Article
Mooser, F; Bosking, WH; Fitzpatrick, D
Published in: Nat Neurosci
August 2004

Feedforward connections are thought to be important in the generation of orientation-selective responses in visual cortex by establishing a bias in the sampling of information from regions of visual space that lie along a neuron's axis of preferred orientation. It remains unclear, however, which structural elements-dendrites or axons-are ultimately responsible for conveying this sampling bias. To explore this question, we have examined the spatial arrangement of feedforward axonal connections that link non-oriented neurons in layer 4 and orientation-selective neurons in layer 2/3 of visual cortex in the tree shrew. Target sites of labeled boutons in layer 2/3 resulting from focal injections of biocytin in layer 4 show an orientation-specific axial bias that is sufficient to confer orientation tuning to layer 2/3 neurons. We conclude that the anisotropic arrangement of axon terminals is the principal source of the orientation bias contributed by feedforward connections.

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Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

August 2004

Volume

7

Issue

8

Start / End Page

872 / 879

Location

United States

Related Subject Headings

  • Visual Perception
  • Visual Pathways
  • Visual Cortex
  • Tupaiidae
  • Orientation
  • Neurology & Neurosurgery
  • Models, Neurological
  • Male
  • Image Processing, Computer-Assisted
  • Female
 

Citation

APA
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MLA
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Mooser, F., Bosking, W. H., & Fitzpatrick, D. (2004). A morphological basis for orientation tuning in primary visual cortex. Nat Neurosci, 7(8), 872–879. https://doi.org/10.1038/nn1287
Mooser, François, William H. Bosking, and David Fitzpatrick. “A morphological basis for orientation tuning in primary visual cortex.Nat Neurosci 7, no. 8 (August 2004): 872–79. https://doi.org/10.1038/nn1287.
Mooser F, Bosking WH, Fitzpatrick D. A morphological basis for orientation tuning in primary visual cortex. Nat Neurosci. 2004 Aug;7(8):872–9.
Mooser, François, et al. “A morphological basis for orientation tuning in primary visual cortex.Nat Neurosci, vol. 7, no. 8, Aug. 2004, pp. 872–79. Pubmed, doi:10.1038/nn1287.
Mooser F, Bosking WH, Fitzpatrick D. A morphological basis for orientation tuning in primary visual cortex. Nat Neurosci. 2004 Aug;7(8):872–879.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

August 2004

Volume

7

Issue

8

Start / End Page

872 / 879

Location

United States

Related Subject Headings

  • Visual Perception
  • Visual Pathways
  • Visual Cortex
  • Tupaiidae
  • Orientation
  • Neurology & Neurosurgery
  • Models, Neurological
  • Male
  • Image Processing, Computer-Assisted
  • Female