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Functional brain maturation in neonates as measured by EEG-sleep analyses.

Publication ,  Journal Article
Scher, MS; Jones, BL; Steppe, DA; Cork, DL; Seltman, HJ; Banks, DL
Published in: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
May 2003

Seven measures of neonatal EEG-sleep behavior were evaluated using multivariate analyses to ascertain if physiologic differences exist between healthy full- and preterm cohorts.A total of 381 24-channel EEG-sleep studies were analyzed, including 125 recordings on 50 healthy fullterm and 256 recordings on 59 asymptomatic preterm infants between 28 and 70.6 weeks post-conceptional age. One EEG study for each subject was randomly assigned (109 studies) within the time window of 38-44 weeks post-conceptional age. A multivariate analytic procedure was applied to the data sets, by which a 'dysmaturity index' was assigned for each infant, based on 7 EEG-sleep measures. This index was defined in terms of the distance from the fullterm group's centroid (i.e. Mahalanobis distance). Receiver-operating characteristic curves (ROCs) were calculated for several different combinations of 7 EEG-sleep measures to describe differences between neonatal cohorts.The ROC curve corresponding to all 7 EEG-sleep measures covered the substantially largest area among the curves for the sets of variables considered, suggesting that all 7 measures of sleep behavior were required to best discriminate between cohorts.This methodology exemplifies how EEG-sleep analyses can be applied to the study of functional brain maturation of infants at risk for neurodevelopment problems.Changes in EEG-sleep behavior in the preterm infant may represent altered activity-dependent development of neural circuitry, resulting in remodeling of the immature brain as a reflection of adaptation to conditions of prematurity.

Duke Scholars

Published In

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

DOI

EISSN

1872-8952

ISSN

1388-2457

Publication Date

May 2003

Volume

114

Issue

5

Start / End Page

875 / 882

Related Subject Headings

  • Sleep
  • Pregnancy
  • Obstetric Labor, Premature
  • Neurology & Neurosurgery
  • Multivariate Analysis
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Scher, M. S., Jones, B. L., Steppe, D. A., Cork, D. L., Seltman, H. J., & Banks, D. L. (2003). Functional brain maturation in neonates as measured by EEG-sleep analyses. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 114(5), 875–882. https://doi.org/10.1016/s1388-2457(03)00026-9
Scher, Mark S., Bobby L. Jones, Doris A. Steppe, Daniel L. Cork, Howard J. Seltman, and David L. Banks. “Functional brain maturation in neonates as measured by EEG-sleep analyses.Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology 114, no. 5 (May 2003): 875–82. https://doi.org/10.1016/s1388-2457(03)00026-9.
Scher MS, Jones BL, Steppe DA, Cork DL, Seltman HJ, Banks DL. Functional brain maturation in neonates as measured by EEG-sleep analyses. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2003 May;114(5):875–82.
Scher, Mark S., et al. “Functional brain maturation in neonates as measured by EEG-sleep analyses.Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 114, no. 5, May 2003, pp. 875–82. Epmc, doi:10.1016/s1388-2457(03)00026-9.
Scher MS, Jones BL, Steppe DA, Cork DL, Seltman HJ, Banks DL. Functional brain maturation in neonates as measured by EEG-sleep analyses. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2003 May;114(5):875–882.
Journal cover image

Published In

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology

DOI

EISSN

1872-8952

ISSN

1388-2457

Publication Date

May 2003

Volume

114

Issue

5

Start / End Page

875 / 882

Related Subject Headings

  • Sleep
  • Pregnancy
  • Obstetric Labor, Premature
  • Neurology & Neurosurgery
  • Multivariate Analysis
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Follow-Up Studies