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Osteomyelitis. Common causes and treatment recommendations.

Publication ,  Journal Article
Dirschl, DR; Almekinders, LC
Published in: Drugs
January 1993

Infections involving bone continue to be a common problem. In children this is usually an acute haematogenous osteomyelitis. Early diagnosis with culture of an aspiration specimen is of paramount importance. Treatment with antibacterial agents is often successful unless pus is obtained in aspiration. In cases with an established abscess, surgical drainage is often needed in addition to antibiotic treatment. Staphylococcus aureus is the most common causative organism, although other microbes are often found in special circumstances such as in neonates, patients with sickle cell disease and those with nail puncture wounds. In adults, a pyogenic osteomyelitis is often due to direct trauma and generally is chronic in nature. Surgical debridement is the mainstay of treatment in these cases. Antibiotic treatment is often helpful but not curative by itself. Fungal and mycobacterial osteomyelitis is especially common in immunocompromised hosts. Amphotericin B remains the preferred treatment for fungal infections. Long term antituberculous multiple drug therapy is often sufficient to treat mycobacterial osteomyelitis.

Duke Scholars

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Published In

Drugs

DOI

ISSN

0012-6667

Publication Date

January 1993

Volume

45

Issue

1

Start / End Page

29 / 43

Location

New Zealand

Related Subject Headings

  • Wounds, Penetrating
  • Suppuration
  • Pharmacology & Pharmacy
  • Osteomyelitis
  • Infant, Newborn
  • Humans
  • Child
  • Anemia, Sickle Cell
  • Adult
  • 3214 Pharmacology and pharmaceutical sciences
 

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Dirschl, D. R., & Almekinders, L. C. (1993). Osteomyelitis. Common causes and treatment recommendations. Drugs, 45(1), 29–43. https://doi.org/10.2165/00003495-199345010-00004
Dirschl, D. R., and L. C. Almekinders. “Osteomyelitis. Common causes and treatment recommendations.Drugs 45, no. 1 (January 1993): 29–43. https://doi.org/10.2165/00003495-199345010-00004.
Dirschl DR, Almekinders LC. Osteomyelitis. Common causes and treatment recommendations. Drugs. 1993 Jan;45(1):29–43.
Dirschl, D. R., and L. C. Almekinders. “Osteomyelitis. Common causes and treatment recommendations.Drugs, vol. 45, no. 1, Jan. 1993, pp. 29–43. Pubmed, doi:10.2165/00003495-199345010-00004.
Dirschl DR, Almekinders LC. Osteomyelitis. Common causes and treatment recommendations. Drugs. 1993 Jan;45(1):29–43.
Journal cover image

Published In

Drugs

DOI

ISSN

0012-6667

Publication Date

January 1993

Volume

45

Issue

1

Start / End Page

29 / 43

Location

New Zealand

Related Subject Headings

  • Wounds, Penetrating
  • Suppuration
  • Pharmacology & Pharmacy
  • Osteomyelitis
  • Infant, Newborn
  • Humans
  • Child
  • Anemia, Sickle Cell
  • Adult
  • 3214 Pharmacology and pharmaceutical sciences