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Tissue factor in experimental acute lung injury.

Publication ,  Journal Article
Welty-Wolf, KE; Carraway, MS; Idell, S; Ortel, TL; Ezban, M; Piantadosi, CA
Published in: Semin Hematol
October 2001

Acute lung injury (ALI) is characterized by fibrin deposition in the tissue and vascular spaces. Coagulation is activated after exposure to endotoxin or bacteria, and a procoagulant environment rapidly develops in the vascular, interstitial, and alveolar spaces of the lung. These changes are tissue factor (TF)-dependent and associated with increases in inflammatory cytokines. Procoagulant changes also occur in the lungs of patients with the acute respiratory distress syndrome (ARDS), suggesting that epithelial inflammation activates the extrinsic pathway. Many inflammatory mediators have specific effects on coagulation; however, the role of TF in regulation of pulmonary inflammatory responses is less clear. Here we report initial data on blockade of TF-initiated coagulation in baboons with Escherichia coli sepsis-induced ALI, using active site-inactivated FVIIa (FVIIai ASIS). Treatment with FVIIai prevented plasma fibrinogen depletion and attenuated fibrin deposition in the tissues. The drug also decreased systemic cytokine responses and inflammatory changes in the lung, including neutrophil infiltration, and decreased edema. Coagulation blockade with FVIIai improved lung function by preserving gas exchange and compliance, decreased pulmonary hypertension, and enhanced renal function. These results show that TF-FVIIa complex is an important regulatory site for the pathologic response of the lung to sepsis.

Duke Scholars

Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

October 2001

Volume

38

Issue

4 Suppl 12

Start / End Page

35 / 38

Location

United States

Related Subject Headings

  • Thromboplastin
  • Respiratory Distress Syndrome
  • Papio
  • Immunology
  • Humans
  • Disease Models, Animal
  • Animals
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Welty-Wolf, K. E., Carraway, M. S., Idell, S., Ortel, T. L., Ezban, M., & Piantadosi, C. A. (2001). Tissue factor in experimental acute lung injury. Semin Hematol, 38(4 Suppl 12), 35–38. https://doi.org/10.1053/shem.2001.29505
Welty-Wolf, K. E., M. S. Carraway, S. Idell, T. L. Ortel, M. Ezban, and C. A. Piantadosi. “Tissue factor in experimental acute lung injury.Semin Hematol 38, no. 4 Suppl 12 (October 2001): 35–38. https://doi.org/10.1053/shem.2001.29505.
Welty-Wolf KE, Carraway MS, Idell S, Ortel TL, Ezban M, Piantadosi CA. Tissue factor in experimental acute lung injury. Semin Hematol. 2001 Oct;38(4 Suppl 12):35–8.
Welty-Wolf, K. E., et al. “Tissue factor in experimental acute lung injury.Semin Hematol, vol. 38, no. 4 Suppl 12, Oct. 2001, pp. 35–38. Pubmed, doi:10.1053/shem.2001.29505.
Welty-Wolf KE, Carraway MS, Idell S, Ortel TL, Ezban M, Piantadosi CA. Tissue factor in experimental acute lung injury. Semin Hematol. 2001 Oct;38(4 Suppl 12):35–38.
Journal cover image

Published In

Semin Hematol

DOI

ISSN

0037-1963

Publication Date

October 2001

Volume

38

Issue

4 Suppl 12

Start / End Page

35 / 38

Location

United States

Related Subject Headings

  • Thromboplastin
  • Respiratory Distress Syndrome
  • Papio
  • Immunology
  • Humans
  • Disease Models, Animal
  • Animals
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology